{"id":"W2522392425","doi":"10.1007/s10549-016-3979-5","title":"Inhibition of EGFR, HER2, and HER3 signaling with AZD8931 in combination with anastrozole as an anticancer approach: Phase II randomized study in women with endocrine-therapy-naïve advanced breast cancer","year":2016,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Jewish General Hospital","funders":"National Institute for Health and Care Research; AstraZeneca; Pfizer","keywords":"Anastrozole; Medicine; Internal medicine; Tolerability; Placebo; Breast cancer; Rash; Combination therapy; Adverse effect; Oncology; Gastroenterology; Cancer; Aromatase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001383625,0.001472053,0.002600249,0.0006599906,0.0004171553,0.0009654044,0.0009754322,0.001315846,0.003211924],"category_scores_gemma":[0.001066397,0.0007842694,0.001310643,0.0006167108,0.001340348,0.001241768,0.000394343,0.003209563,0.0006878174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008935389,"about_ca_system_score_gemma":0.001190594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319175,"about_ca_topic_score_gemma":0.003601419,"domain_scores_codex":[0.9994546,0.0002734211,0.00002717409,0.00008812182,0.00004601857,0.0001107249],"domain_scores_gemma":[0.999471,0.0001375084,0.00008216986,0.00005321652,0.00002373073,0.0002324152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9327767,0.01966629,0.002017237,0.0002499143,0.0009387034,0.00005163656,0.00007520402,0.0008680022,0.008342844,0.0001408335,0.0007374705,0.03413498],"study_design_scores_gemma":[0.7753814,0.2159454,0.004706544,0.00001497435,0.0007585415,0.00005659792,0.00004062101,0.0007037317,0.001342259,0.0001560138,0.0008716103,0.00002231829],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938319,0.002705346,0.0003453616,0.0004286388,0.0001630083,0.0008883656,0.0004755613,0.00008329393,0.001078569],"genre_scores_gemma":[0.991909,0.002622105,0.0009449478,0.0005135863,0.0002126509,0.001123995,0.0008674968,0.00002614951,0.001780141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211924,"threshold_uncertainty_score":0.01074493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.041784829547201,"score_gpt":0.392317485535919,"score_spread":0.350532655988718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}