{"id":"W2522406802","doi":"10.3389/fimmu.2016.00357","title":"Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis","year":2016,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Fondation pour la Recherche Médicale; Queensland Health; Stiftung Vinetum; Mater Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Intensive Care Foundation","keywords":"Exome sequencing; Pseudomonas aeruginosa; Sepsis; Medicine; Primary immunodeficiency; Immunology; Biology; Genetics; Gene; Bacteria; Phenotype; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274728,0.0004297303,0.0003316414,0.0007969855,0.000477508,0.000529322,0.0002946685,0.001005606,0.001639416],"category_scores_gemma":[0.001613606,0.0001669895,0.0002624537,0.0009561696,0.0003174156,0.0002310484,0.0005778797,0.000472033,0.0003486483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511318,"about_ca_system_score_gemma":0.0001946371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002188153,"about_ca_topic_score_gemma":0.002955416,"domain_scores_codex":[0.9996259,0.00004912825,0.00003667919,0.000107966,0.0001138516,0.00006646152],"domain_scores_gemma":[0.9995409,0.0001953126,0.0001141588,0.00002357053,0.00005940291,0.00006662124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009366514,0.00008874768,0.8431633,0.0002388927,0.0001934686,0.04043339,0.001112356,0.0009347667,0.074854,0.0005406314,0.005625257,0.03187849],"study_design_scores_gemma":[0.00003037052,0.0001497595,0.9515065,0.00009104143,0.00008241216,0.03852236,0.0006197577,0.0006099006,0.003752347,0.0003983808,0.004218633,0.00001856878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930493,0.001595916,0.0005157369,0.0004149638,0.00001975992,0.00001945708,0.00304627,0.00003113891,0.001307474],"genre_scores_gemma":[0.9957343,0.0009146581,0.0009549744,0.0003706675,0.00002375608,0.00002040904,0.001732782,0.00001773967,0.0002307335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002188153,"threshold_uncertainty_score":0.005484402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487207715718979,"score_gpt":0.2569835615327135,"score_spread":0.2421114843755237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}