{"id":"W2522490287","doi":"10.1016/bs.irn.2016.06.001","title":"From the Blood to the Central Nervous System","year":2016,"lang":"en","type":"review","venue":"International review of neurobiology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Transcytosis; Endocytosis; Exocytosis; Blood–brain barrier; Central nervous system; Neuroscience; Cell biology; Receptor; Biology; Chemistry; Secretion; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006706569,0.0002911239,0.001077579,0.00004102184,0.00005363724,0.00002978921,0.002407763,0.00009194524,0.000606372],"category_scores_gemma":[0.0006999233,0.0001188574,0.000451387,0.0001421267,0.0001317588,0.0000438973,0.0004471505,0.0001663275,0.002323867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008503036,"about_ca_system_score_gemma":0.0001926793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000779287,"about_ca_topic_score_gemma":0.000006737711,"domain_scores_codex":[0.9968094,0.001105615,0.001032282,0.0004737742,0.0002726372,0.00030629],"domain_scores_gemma":[0.9964717,0.001749737,0.0007284153,0.0008111236,0.0001720054,0.00006699157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002501352,0.0001249201,0.000007204777,0.02506906,0.00038725,0.00007393162,0.00004228487,0.000002979629,0.004133729,0.005705945,0.05035071,0.914077],"study_design_scores_gemma":[0.00006347642,0.00003939549,0.000007850737,0.06262493,0.000356937,0.0001059341,0.000001942483,3.98799e-7,0.0001889093,0.000009197021,0.9364843,0.0001166876],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003415851,0.9893332,0.00002790517,0.003388104,0.004320017,0.001005398,0.001352279,0.00003562404,0.0001959583],"genre_scores_gemma":[0.0002046043,0.9962644,0.00003663281,0.002055043,0.001058765,0.0001667871,0.00006366811,0.00002713618,0.0001229481],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9139603,"threshold_uncertainty_score":0.998453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02543698882885746,"score_gpt":0.3035463255847049,"score_spread":0.2781093367558474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}