{"id":"W2522885072","doi":"10.1038/ncomms12918","title":"The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"U.S. Department of Defense; University of Minnesota; Howard Hughes Medical Institute; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Science Foundation","keywords":"APOBEC; Mutagenesis; Cytosine deaminase; Genetics; Biology; Mutation; Cancer research; Gene; Cytosine; Cancer; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179672,0.0001031874,0.00008224735,0.00003053439,0.0003898588,0.00004095933,0.000458123,0.000183346,0.000003461437],"category_scores_gemma":[0.0002325099,0.00006421296,0.00003662509,0.0001193765,0.0001240648,0.000003788041,0.0003442313,0.0001096314,0.000003255627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002403877,"about_ca_system_score_gemma":0.00005622415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000310632,"about_ca_topic_score_gemma":0.001446199,"domain_scores_codex":[0.9993496,0.00009643648,0.0001422231,0.0001829045,0.00007334605,0.0001554723],"domain_scores_gemma":[0.9984782,0.0001482449,0.0000580042,0.001014504,0.0002284959,0.0000724934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004502444,0.00003389322,0.02220679,0.000004030869,0.00007670501,1.512128e-7,0.00002207219,0.000002953914,0.9352853,0.002073519,0.002873488,0.03737608],"study_design_scores_gemma":[0.0005607263,0.00006649229,0.1939957,0.00005347623,0.00008387625,0.000003828718,0.00002426356,0.00008560919,0.3420098,0.0002604619,0.4626141,0.0002416302],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8010257,0.1587203,0.002402975,0.03659542,0.0001950539,0.0004153773,0.000217244,0.00002419194,0.0004037484],"genre_scores_gemma":[0.9837453,0.01442899,0.0006787891,0.0003799525,0.00007583109,0.00008856053,0.00004323421,0.00001725093,0.0005420483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5932755,"threshold_uncertainty_score":0.2998518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007492458700017981,"score_gpt":0.2954787368944919,"score_spread":0.287986278194474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}