{"id":"W2523121066","doi":"10.1016/j.ebiom.2016.09.015","title":"Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically","year":2016,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; University of British Columbia; Eberhard Karls Universität Tübingen","keywords":"Abscess; Antibiotics; Staphylococcus aureus; Medicine; Microbiology; Pseudomonas aeruginosa; Stringent response; Mediator; Therapeutic modalities; Bacteria; Immunology; Biology; Surgery; Internal medicine; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636993,0.0003197506,0.0002761763,0.000122887,0.0001085147,0.0002590468,0.00008906173,0.0002848249,0.0008729745],"category_scores_gemma":[0.0001419489,0.00007647357,0.0001396136,0.0000596316,0.0003173478,0.0002242504,0.000279493,0.0005909565,0.0002136328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008445723,"about_ca_system_score_gemma":0.0001182022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004664267,"about_ca_topic_score_gemma":0.000106088,"domain_scores_codex":[0.9998648,0.00004766965,0.00000884668,0.00001844026,0.00002641526,0.00003374461],"domain_scores_gemma":[0.9998478,0.00002581094,0.00006618705,0.0000135642,0.00001338671,0.00003331359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005192713,0.00002161734,0.0001113681,0.00004478401,0.000001707907,0.00009044824,0.000007802046,0.00002979261,0.9969997,0.00007773389,0.00002660092,0.002536659],"study_design_scores_gemma":[0.00003138318,0.002613292,0.008769977,0.00004357307,0.00001510735,0.001842145,0.0001224554,0.0008256848,0.9795568,0.0004927749,0.005676418,0.00001038556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763463,0.009963759,0.01053357,0.0004278161,0.00008145541,0.00008570968,0.00008538905,0.000135635,0.002340443],"genre_scores_gemma":[0.9935725,0.002830675,0.002503785,0.00007602436,0.00002870387,0.00003678262,0.00004661987,0.000007358159,0.0008975497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008729745,"threshold_uncertainty_score":0.002920389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029039717961259,"score_gpt":0.2309792493189068,"score_spread":0.2206888521392942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}