{"id":"W2523170917","doi":"10.1371/journal.pone.0162731","title":"Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian HIV Trials Network, Canadian Institutes of Health Research; British Heart Foundation; Agence Universitaire de la Francophonie; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Atorvastatin; RHOA; Renal cortex; Endocrinology; Diabetic nephropathy; Internal medicine; Protein kinase B; Medicine; Kidney; Downregulation and upregulation; Diabetes mellitus; Kidney disease; Albuminuria; Statin; Chemistry; Phosphorylation; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314261,0.0004851237,0.0006138652,0.0005828722,0.0002635836,0.0003798851,0.0002741981,0.0003511434,0.001502713],"category_scores_gemma":[0.00007990217,0.0002480013,0.0005821973,0.0003096189,0.0003307072,0.0003219745,0.0002044048,0.0009823627,0.0002815054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357527,"about_ca_system_score_gemma":0.0003899714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009492311,"about_ca_topic_score_gemma":0.001566332,"domain_scores_codex":[0.9997873,0.00002647788,0.00003101,0.00003706752,0.00004107475,0.00007713372],"domain_scores_gemma":[0.9998394,0.000006282961,0.0000487186,0.00001437633,0.00001742639,0.00007368353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001220489,0.0001182698,0.0004220904,0.00009868226,0.00001944771,0.00005545459,0.00001327452,0.00002862264,0.9965212,0.00008169157,0.00004224955,0.001378384],"study_design_scores_gemma":[0.0002122387,0.001640717,0.02112337,0.00002343623,0.0001335242,0.0003361444,0.00009218414,0.0008751127,0.9736124,0.0001452484,0.001792236,0.00001342029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934108,0.00274867,0.001768628,0.0002983876,0.00006405773,0.00002773199,0.0005777619,0.0001411881,0.0009628222],"genre_scores_gemma":[0.9914396,0.002601949,0.002190368,0.0001485802,0.0000295015,0.0000650806,0.0005867349,0.00002717889,0.002911043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502713,"threshold_uncertainty_score":0.005027115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253706147591226,"score_gpt":0.2140333996155735,"score_spread":0.2014963381396612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}