{"id":"W2523207814","doi":"10.1093/aje/kww014","title":"Accounting for Life-Course Exposures in Epigenetic Biomarker Association Studies: Early Life Socioeconomic Position, Candidate Gene DNA Methylation, and Adult Cardiometabolic Risk","year":2016,"lang":"en","type":"article","venue":"American Journal of Epidemiology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Life course approach; DNA methylation; Epigenetics; Confounding; Methylation; Socioeconomic status; Medicine; Biomarker; Demography; Genetics; Physiology; Biology; Psychology; Internal medicine; Developmental psychology; Gene; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01268416,0.0009954296,0.0008608326,0.001050906,0.0008992018,0.0009833921,0.001686785,0.0009424957,0.003008476],"category_scores_gemma":[0.03460489,0.0005348407,0.002500328,0.002467164,0.000732031,0.00103638,0.001255201,0.001085029,0.0002404278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007314538,"about_ca_system_score_gemma":0.002288815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02340211,"about_ca_topic_score_gemma":0.04581662,"domain_scores_codex":[0.9897718,0.0070587,0.0006644863,0.001500308,0.0005575002,0.0004472208],"domain_scores_gemma":[0.9871236,0.008147727,0.001417047,0.002460273,0.0004926231,0.0003587285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008981683,0.0001123113,0.9616832,0.0002020263,0.004414396,0.0002230911,0.0004414455,0.004242382,0.001793654,0.002025686,0.0004839454,0.02347972],"study_design_scores_gemma":[0.0001016167,0.001050595,0.9567192,0.000102841,0.002366602,0.0002409188,0.0002604109,0.02978681,0.001597521,0.00497545,0.002753894,0.00004414457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8852577,0.004237937,0.104391,0.001346924,0.0001950806,0.0003654312,0.002465613,0.0002354849,0.00150472],"genre_scores_gemma":[0.980416,0.0004732834,0.01627959,0.0001400248,0.00005649826,0.0003344624,0.0009278129,0.00003432863,0.001338143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02340211,"threshold_uncertainty_score":0.06708109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02958724923061989,"score_gpt":0.3492092473943398,"score_spread":0.3196219981637199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}