{"id":"W2523207833","doi":"10.1182/blood.v110.11.1529.1529","title":"Inducible Expression of Leukemia-Associated Shp2 (Ptpn11) Affects Multiple Stages of Hematopoiesis and Causes a Fatal Myeloproliferative Disorder (MPD) in Mice","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"PTPN11; Juvenile myelomonocytic leukemia; Biology; Leukemia; Cancer research; Bone marrow; Progenitor cell; Haematopoiesis; Myeloid leukemia; Myeloid; Transplantation; Immunology; Stem cell; Mutation; Internal medicine; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198873,0.0007769254,0.0002253448,0.0004632125,0.0002350132,0.0003067659,0.0003454674,0.0006480082,0.001942889],"category_scores_gemma":[0.00009447838,0.0003218091,0.0003673414,0.0002041821,0.0003946753,0.0002172834,0.0003823896,0.001065443,0.0006255792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004289187,"about_ca_system_score_gemma":0.0001929319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006333801,"about_ca_topic_score_gemma":0.001168386,"domain_scores_codex":[0.9996891,0.00004057811,0.00003918274,0.00007997381,0.00007998006,0.00007120185],"domain_scores_gemma":[0.9997234,0.00003517896,0.00008028399,0.00002421071,0.00001095525,0.0001258942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049492,0.00006213573,0.0002344656,0.00002541199,0.000008719575,0.0001144805,0.00001370731,0.00009651197,0.9985881,0.0001644378,0.00005024617,0.0005367534],"study_design_scores_gemma":[0.0001087902,0.0005979553,0.005560697,0.00002065287,0.00003789468,0.0009303649,0.00004306953,0.00207938,0.9867548,0.0001022578,0.003755388,0.000008785844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915303,0.0007431392,0.003589232,0.0001531269,0.00005465513,0.00008469303,0.001713602,0.0002332916,0.001898023],"genre_scores_gemma":[0.9901156,0.0005896706,0.002242447,0.00009169497,0.00001572554,0.000100061,0.001192827,0.00006827788,0.005583669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942889,"threshold_uncertainty_score":0.006499648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007445077322978879,"score_gpt":0.2374279216397059,"score_spread":0.229982844316727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}