{"id":"W2523237690","doi":"10.1182/blood.v124.21.116.116","title":"Phase 1/1b Study of RG7388, a Potent MDM2 Antagonist, in Acute Myelogenous Leukemia (AML) Patients (Pts)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Refractory (planetary science); Pharmacodynamics; Pharmacokinetics; Adverse effect; Cytarabine; Pharmacology; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006464173,0.0002928328,0.0007239597,0.0003890056,0.00008819163,0.00001979669,0.0003593243,0.0001629662,0.00004464559],"category_scores_gemma":[0.0002714607,0.0002524283,0.0001158,0.0005503278,0.0001085882,0.00008489182,0.0002292871,0.0005222533,0.0000863629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004732746,"about_ca_system_score_gemma":0.0004548576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007596869,"about_ca_topic_score_gemma":0.0001026341,"domain_scores_codex":[0.9970438,0.0002533742,0.0006768649,0.0005495659,0.0008330178,0.0006433318],"domain_scores_gemma":[0.9983195,0.0001172957,0.0001793132,0.0008575924,0.0002413798,0.0002849006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.005667354,0.201838,0.5811343,0.0005666179,0.00249765,0.002574926,0.01141246,0.0000446556,0.09890582,0.0001025329,0.002985989,0.09226967],"study_design_scores_gemma":[0.4791901,0.05255513,0.3894414,0.0003622005,0.002290131,0.0003208822,0.002401973,0.002277188,0.06618773,0.0001044785,0.003740603,0.001128191],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956799,0.00007315203,0.00005141609,0.000104922,0.00008408023,0.001586601,0.00003714834,0.00006015813,0.002322697],"genre_scores_gemma":[0.9986902,0.0000510988,0.0003266228,0.0002070293,0.0001352369,0.00008571481,0.00007979126,0.00006118788,0.0003630465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4735227,"threshold_uncertainty_score":0.9999928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520651691423323,"score_gpt":0.2954112388877334,"score_spread":0.2802047219735002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}