{"id":"W2523237690","doi":"10.1182/blood.v124.21.116.116","title":"Phase 1/1b Study of RG7388, a Potent MDM2 Antagonist, in Acute Myelogenous Leukemia (AML) Patients (Pts)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Refractory (planetary science); Pharmacodynamics; Pharmacokinetics; Adverse effect; Cytarabine; Pharmacology; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00083866,0.001135935,0.001119424,0.0002563934,0.0002269228,0.0005333407,0.0004684868,0.0005664339,0.002514491],"category_scores_gemma":[0.0004766901,0.0003217523,0.0004242152,0.0002908108,0.0004387108,0.0004024622,0.0002817572,0.001711914,0.0006780202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000571142,"about_ca_system_score_gemma":0.0007158554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004754252,"about_ca_topic_score_gemma":0.000980139,"domain_scores_codex":[0.9997225,0.0001366839,0.00001312369,0.00004704706,0.00003164662,0.00004885602],"domain_scores_gemma":[0.9997188,0.00004314219,0.00006958081,0.00002386281,0.0000170412,0.0001274479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4347228,0.102788,0.02228853,0.000865996,0.000923002,0.0009142557,0.0005085563,0.006418401,0.202579,0.0005300742,0.008497264,0.218964],"study_design_scores_gemma":[0.2579274,0.674585,0.04415043,0.00003840261,0.0003081268,0.001032998,0.00008129593,0.001785585,0.01190663,0.000278043,0.007880951,0.00002501681],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965791,0.0007121403,0.0002860671,0.0001713507,0.0000182105,0.0008044569,0.0004622514,0.00004374094,0.0009227103],"genre_scores_gemma":[0.9917041,0.0008831116,0.001496667,0.0005379225,0.00008480196,0.001056942,0.001928098,0.00003047242,0.002278042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002514491,"threshold_uncertainty_score":0.008411765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520651691423323,"score_gpt":0.2954112388877334,"score_spread":0.2802047219735002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}