{"id":"W2523288082","doi":"10.1182/blood.v112.11.867.867","title":"Preliminary Results of CNTO 328, An Anti-Interleukin-6 Monoclonal Antibody, in Combination with Bortezomib in the Treatment of Relapsed or Refractory Multiple Myeloma","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Bortezomib; Medicine; Multiple myeloma; Regimen; Lenalidomide; Dexamethasone; Internal medicine; Transplantation; Oncology; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009427606,0.001006386,0.001396204,0.0002588666,0.000423265,0.0006190741,0.0005084067,0.0005128664,0.00132531],"category_scores_gemma":[0.0007846211,0.0003080143,0.0007581652,0.0002604408,0.0005119857,0.0004373411,0.0002614759,0.001811407,0.0003265207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005273017,"about_ca_system_score_gemma":0.000587289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004895,"about_ca_topic_score_gemma":0.002236356,"domain_scores_codex":[0.9996058,0.0001971262,0.00002838137,0.00004770965,0.00004425,0.00007673318],"domain_scores_gemma":[0.9994873,0.0001508541,0.00008528854,0.0000419611,0.00003367234,0.0002008256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2971362,0.06757988,0.01540411,0.001228962,0.001539298,0.0027239,0.001137303,0.004521043,0.3899456,0.0002930625,0.003839956,0.2146507],"study_design_scores_gemma":[0.0791204,0.8153425,0.04211261,0.00007225365,0.001069418,0.002054467,0.000167898,0.002137977,0.05101049,0.0001569225,0.006710108,0.00004499353],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949117,0.002690984,0.0004748436,0.0002314766,0.000065755,0.0003770296,0.0002125121,0.00003973205,0.0009960009],"genre_scores_gemma":[0.9963003,0.001397817,0.0005843007,0.0001720546,0.0001114585,0.0001989916,0.0005257683,0.00001560491,0.0006936685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001396204,"threshold_uncertainty_score":0.004985869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03800804186316246,"score_gpt":0.3136729158029968,"score_spread":0.2756648739398344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}