{"id":"W2523333069","doi":"10.1126/science.aah5324","title":"Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":282,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Ministry of Science and Technology; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Gating; Biophysics; Endoplasmic reticulum; Calcium; Chemistry; Cytoplasm; Cardiac muscle; Calcium channel; Receptor; Contraction (grammar); Cell biology; Anatomy; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251436,0.00003263526,0.00002522025,0.00000936023,0.000176644,0.000007438667,0.0001809456,0.00002111235,0.00003757493],"category_scores_gemma":[0.0003720534,0.00001328503,0.00002759812,0.0001198351,0.0001703566,0.000003720986,0.00005348834,0.00001100435,0.000001852241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007668707,"about_ca_system_score_gemma":0.00005400928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001460335,"about_ca_topic_score_gemma":0.000001990641,"domain_scores_codex":[0.999638,0.000009118632,0.00006012027,0.0001083452,0.0001017011,0.00008270588],"domain_scores_gemma":[0.9996316,0.00001815206,0.00004777625,0.0001530522,0.0001351942,0.00001423795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001148453,9.710246e-7,0.0001055958,0.000001166807,0.000001557039,1.629521e-9,0.00002081195,0.00001423601,0.9937454,0.001654215,0.0002246413,0.004219951],"study_design_scores_gemma":[0.0001024483,0.00005601578,0.001751497,0.000006887575,0.000002519222,9.40642e-7,0.00005605549,0.0008869174,0.9900368,0.0004136432,0.006653422,0.00003278019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860315,0.00004822974,0.009795988,0.001752203,0.001967742,0.0001738378,0.00001104078,0.000004486179,0.0002149215],"genre_scores_gemma":[0.9983,0.000007419115,0.0003021915,0.00009891466,0.0001546638,0.00000389962,8.380173e-7,0.000002486966,0.001129634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0122684,"threshold_uncertainty_score":0.1358621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822426931873709,"score_gpt":0.2575549976926912,"score_spread":0.2393307283739541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}