{"id":"W2523333069","doi":"10.1126/science.aah5324","title":"Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":282,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Ministry of Science and Technology; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Gating; Biophysics; Endoplasmic reticulum; Calcium; Chemistry; Cytoplasm; Cardiac muscle; Calcium channel; Receptor; Contraction (grammar); Cell biology; Anatomy; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007048115,0.0001828759,0.000122982,0.00007109434,0.000188218,0.0002087632,0.0002378846,0.0003162647,0.0003410744],"category_scores_gemma":[0.0001162376,0.00008973468,0.0001271721,0.00004975604,0.0002578704,0.0002454556,0.0001625937,0.0002894772,0.0001310742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001477407,"about_ca_system_score_gemma":0.0001541989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002986419,"about_ca_topic_score_gemma":0.0002787864,"domain_scores_codex":[0.999975,0.000003453987,0.000002191958,0.000007023872,0.000008045539,0.000004443054],"domain_scores_gemma":[0.9999698,0.000003069142,0.00001056905,0.000004964602,0.000004877422,0.000006575612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005635765,0.00001001522,0.0004886152,0.00003503196,0.000004672318,0.0002938588,0.0000478418,0.001009382,0.9961888,0.0007638579,0.00005300445,0.001048557],"study_design_scores_gemma":[0.0001243566,0.000562543,0.07404998,0.0000491407,0.00006554991,0.005109601,0.0004897278,0.04541457,0.8572999,0.005960961,0.0107973,0.00007633872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922075,0.0007196956,0.005903685,0.0002148646,0.00002078173,0.000007214665,0.00007177419,0.00004499183,0.000809543],"genre_scores_gemma":[0.9975179,0.0003975093,0.00159438,0.00003178992,0.000008805207,0.00000508261,0.0001747119,0.000005967626,0.0002638702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003410744,"threshold_uncertainty_score":0.001141071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822426931873709,"score_gpt":0.2575549976926912,"score_spread":0.2393307283739541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}