{"id":"W2523446095","doi":"10.1083/jcb.201603106","title":"Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Vascular Anomalies and Treatments","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; National Institutes of Health; National Eye Institute; Belgian American Educational Foundation; American Heart Association","keywords":"Endoglin; Mechanotransduction; Cell biology; Mural cell; Bone morphogenetic protein; Phenotype; Angiogenesis; ACVRL1; Receptor; Telangiectasia; Biology; Endothelial stem cell; Pathology; Cancer research; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265091,0.0003038968,0.0001593814,0.0002758032,0.0001202223,0.0001778991,0.0001627107,0.0002800694,0.0009730964],"category_scores_gemma":[0.0001770783,0.0001326485,0.00009945765,0.0001058065,0.0003769693,0.0001404041,0.0002615821,0.0002902239,0.0001813245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081018,"about_ca_system_score_gemma":0.0001092574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292971,"about_ca_topic_score_gemma":0.0002785932,"domain_scores_codex":[0.9998934,0.00002897245,0.000009622157,0.00001695672,0.0000300101,0.00002089536],"domain_scores_gemma":[0.9999309,0.00001614049,0.00002576365,0.000005784668,0.000003815561,0.00001759561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001768579,0.00003935165,0.001224185,0.00002720231,0.00000667226,0.001027519,0.00002669367,0.00007934429,0.9950885,0.0003845576,0.00006912629,0.001849958],"study_design_scores_gemma":[0.00008318892,0.0006136005,0.03447843,0.000008227924,0.00003289368,0.008295,0.00006025826,0.002023893,0.9519112,0.0004856767,0.001997155,0.00001048261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984952,0.0003422167,0.0005321263,0.00004357918,0.000006645764,0.00000729694,0.00004007587,0.00002845779,0.000504319],"genre_scores_gemma":[0.9991731,0.0002063284,0.0002621284,0.00001145548,0.000004348358,0.000005862918,0.00003905324,0.00000276688,0.000294846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009730964,"threshold_uncertainty_score":0.003255367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008669470227175456,"score_gpt":0.2334392145330027,"score_spread":0.2247697443058272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}