{"id":"W2523564199","doi":"10.1161/atvbaha.114.304406","title":"PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial Hypercholesterolemia","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; Internal medicine; Endocrinology; Familial hypercholesterolemia; Apolipoprotein B; Lipoprotein; Medicine; Population; Cholesterol; Kexin; Missense mutation; Odds ratio; LDL receptor; Biology; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00157134,0.0003719205,0.001121044,0.000168305,0.0001957916,0.000049785,0.0001104373,0.0002736083,0.00002735068],"category_scores_gemma":[0.0001392384,0.0003069834,0.000654102,0.0001895818,0.0003171985,0.000112546,0.0001617265,0.0003524567,0.00001875965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004377745,"about_ca_system_score_gemma":0.00005094103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009329362,"about_ca_topic_score_gemma":0.00007858343,"domain_scores_codex":[0.9971178,0.0005898075,0.0004433154,0.0009764367,0.000299875,0.000572731],"domain_scores_gemma":[0.9981234,0.00005397091,0.00006904791,0.001199593,0.00006396594,0.0004900117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003712934,0.000260385,0.9460472,0.0002192118,0.001426235,0.000001253786,0.0002505314,0.00001550498,0.006283214,0.0002653895,0.00003739572,0.04515648],"study_design_scores_gemma":[0.00393483,0.000545667,0.9749913,0.0001587405,0.0007812417,0.000003455674,0.00007231133,0.0003439572,0.00002220257,0.0001164428,0.01870404,0.0003258083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955197,0.002141196,0.0008805002,0.0003781113,0.0002224653,0.0006473309,0.0000249432,0.00006066337,0.0001251089],"genre_scores_gemma":[0.9790003,0.01913962,0.0004238485,0.0009252084,0.0003242272,0.0001031821,0.00003261719,0.00004811017,0.000002886298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04483066,"threshold_uncertainty_score":0.9999382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227223013071389,"score_gpt":0.2580730135167958,"score_spread":0.2353507122096569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}