{"id":"W2523564199","doi":"10.1161/atvbaha.114.304406","title":"PCSK9 R46L, Lower LDL, and Cardiovascular Disease Risk in Familial Hypercholesterolemia","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; Internal medicine; Endocrinology; Familial hypercholesterolemia; Apolipoprotein B; Lipoprotein; Medicine; Population; Cholesterol; Kexin; Missense mutation; Odds ratio; LDL receptor; Biology; Genetics; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005289267,0.0003235055,0.0002356318,0.0004410311,0.0003766081,0.0003745142,0.0001841166,0.0005266678,0.002006038],"category_scores_gemma":[0.001280434,0.0002177839,0.0003007855,0.0003110144,0.0001814399,0.0001809606,0.0002077563,0.000446608,0.0002477983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147173,"about_ca_system_score_gemma":0.0001444409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584821,"about_ca_topic_score_gemma":0.001504411,"domain_scores_codex":[0.9997668,0.00007150817,0.00002358827,0.00005664752,0.00004711348,0.00003436258],"domain_scores_gemma":[0.9993352,0.0001170418,0.0002785262,0.00005098966,0.00006044827,0.0001577339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004620515,0.00008266752,0.9966257,0.000007689418,0.00008288691,0.0001639248,0.00004665787,0.0000280511,0.001494245,0.00001225403,0.00007160455,0.0009222369],"study_design_scores_gemma":[0.000032785,0.0002562777,0.9979395,0.000005774096,0.00007247974,0.0009672184,0.0000479288,0.0002809305,0.000270716,0.0000213378,0.0001021018,0.000002982648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995371,0.0001537597,0.00006473072,0.00004597263,0.000005648366,0.000002735193,0.0000604316,0.000002791711,0.0001269368],"genre_scores_gemma":[0.9995543,0.00005233267,0.00008625344,0.0000203849,0.00001439784,0.000003096721,0.00007214612,0.00000119169,0.0001958757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006038,"threshold_uncertainty_score":0.006710827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227223013071389,"score_gpt":0.2580730135167958,"score_spread":0.2353507122096569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}