{"id":"W2523618748","doi":"10.1530/eje-16-0357","title":"Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study","year":2016,"lang":"en","type":"article","venue":"European Journal of Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"National Institute for Health and Care Research","keywords":"Turner syndrome; Human growth hormone; Endocrinology; Internal medicine; Recombinant DNA; Growth hormone deficiency; Growth hormone; Turner's syndrome; Hormone; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705821,0.0002822636,0.0005893731,0.0006984463,0.0001192877,0.00002206131,0.0003690286,0.00003562111,0.00001166598],"category_scores_gemma":[0.0007504833,0.0001502976,0.00008595854,0.0004838515,0.0002365871,0.0001774699,0.0001706787,0.0004059587,0.000008056117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000806291,"about_ca_system_score_gemma":0.00008334575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003516905,"about_ca_topic_score_gemma":0.000001888936,"domain_scores_codex":[0.9961786,0.001492323,0.001046737,0.000350537,0.0004432652,0.0004885338],"domain_scores_gemma":[0.9982513,0.0002469902,0.0006171628,0.0003636424,0.0003124072,0.0002084569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004586068,0.0005767063,0.9136872,0.00001421466,0.0002338565,0.001450431,0.000929885,0.000003462087,0.07561427,0.00003911259,0.000377856,0.002486957],"study_design_scores_gemma":[0.007351758,0.02403609,0.9590426,0.0001306011,0.0002210462,0.006519388,0.0004853807,8.122652e-7,0.001981552,0.00003486861,0.00002379758,0.0001720732],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970604,0.0005688159,0.0001528245,0.001180175,0.00007341631,0.0006959217,0.000005135005,0.00001807422,0.0002452933],"genre_scores_gemma":[0.9990321,0.0003109836,0.0004040583,0.00007417857,0.00005546794,0.000006115581,0.000001463863,0.00005411462,0.00006148751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07363272,"threshold_uncertainty_score":0.6128957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131296835387744,"score_gpt":0.2380907166432805,"score_spread":0.2249610331045061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}