{"id":"W2523728469","doi":"10.1101/067827","title":"GTSE1 tunes microtubule stability for chromosome alignment and segregation through MCAK inhibition","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering; Dartmouth College","keywords":"Microtubule; Chromosome segregation; Mitosis; Chromosome instability; Cell biology; Chromosome; Biology; Kinetochore; Spindle apparatus; Multipolar spindles; Cancer cell; Cell division; Genetics; Chemistry; Cell; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036374,0.000315767,0.0002498175,0.0002170561,0.0001479957,0.000447286,0.0002320678,0.0002419005,0.001794756],"category_scores_gemma":[0.0001244397,0.0001282996,0.0001820178,0.0001652551,0.0002690394,0.0001662384,0.000268093,0.0004446569,0.0005409734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005790052,"about_ca_system_score_gemma":0.000210761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008286222,"about_ca_topic_score_gemma":0.001329043,"domain_scores_codex":[0.9999084,0.000009217681,0.000009065898,0.00002694311,0.00002713341,0.00001909793],"domain_scores_gemma":[0.9999145,0.00001398683,0.00003014613,0.00001079232,0.000007754639,0.00002277101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000878553,0.00001696545,0.0002260062,0.00002118529,0.000004078638,0.00001804637,0.000005058333,0.0001053816,0.9984655,0.0001299924,0.00006089914,0.0008590395],"study_design_scores_gemma":[0.000007831837,0.00003827717,0.001463054,0.000002444888,0.000003823567,0.00004263763,0.000005859374,0.0007535832,0.9961958,0.00002970603,0.001454917,0.00000209506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940177,0.001273265,0.001757503,0.0002074759,0.00003565345,0.00001701008,0.0005388752,0.0001530228,0.001999473],"genre_scores_gemma":[0.9946482,0.0005652463,0.001074378,0.00004831207,0.000006754691,0.00001311951,0.000439704,0.00005062946,0.003153766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794756,"threshold_uncertainty_score":0.006004035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258978456242877,"score_gpt":0.2232100089981227,"score_spread":0.2106202244356939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}