{"id":"W2523790029","doi":"10.1136/bmj.i5309","title":"Revisiting the drug interaction between tamoxifen and SSRI antidepressants","year":2016,"lang":"en","type":"letter","venue":"BMJ","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre","funders":"","keywords":"Tamoxifen; CYP2D6; Breast cancer; Drug; Medicine; Harm; Pharmacology; Antidepressant; Attribution; Psychology; Psychiatry; Cancer; Internal medicine; Cytochrome P450; Anxiety; Social psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01828893,0.0007398641,0.002339574,0.003007718,0.001440079,0.004371504,0.002378796,0.007780161,0.004175787],"category_scores_gemma":[0.07547646,0.0008106063,0.002075748,0.002237244,0.003794385,0.009705543,0.00231394,0.01467963,0.002021051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004339557,"about_ca_system_score_gemma":0.006202121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01260849,"about_ca_topic_score_gemma":0.03742975,"domain_scores_codex":[0.9794581,0.009422877,0.00438623,0.001415973,0.004825568,0.0004912689],"domain_scores_gemma":[0.8817269,0.09325951,0.008191125,0.001831179,0.01380854,0.001182879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005058316,0.0001653267,0.01232951,0.01661471,0.001605728,0.008602903,0.004321855,0.0005348902,0.001308206,0.02519535,0.4370738,0.4917418],"study_design_scores_gemma":[0.000140115,0.0002780491,0.006982862,0.0198182,0.001069467,0.008588907,0.003537425,0.0005391202,0.0004722617,0.01889979,0.9395457,0.000128059],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003732352,0.3644189,0.001765555,0.600087,0.0232192,0.00004637519,0.0002080288,0.00005409744,0.006468497],"genre_scores_gemma":[0.04638305,0.459672,0.00373896,0.3606634,0.1242267,0.00006148182,0.0002822681,0.00013449,0.004837628],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01828893,"threshold_uncertainty_score":0.0967223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1393448381394833,"score_gpt":0.4614536018219248,"score_spread":0.3221087636824415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}