{"id":"W2523841505","doi":"10.1038/srep33968","title":"Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Congressionally Directed Medical Research Programs; Fonds de Recherche du Québec - Santé; Movember Canada; Astellas Pharma; Prostate Cancer Canada; DOD Prostate Cancer Research Program; Movember Foundation; Canadian Urological Association; Université Laval","keywords":"Antiandrogens; Androgen receptor; Cell; Single-cell analysis; Population; Cell biology; Bioluminescence; Chemistry; Receptor; Biology; Prostate cancer; Internal medicine; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007750981,0.0006686702,0.0005068391,0.0007277434,0.0002649528,0.0004855252,0.0006898554,0.0007567273,0.0008304561],"category_scores_gemma":[0.0005605206,0.0003953541,0.0003195873,0.0003372721,0.0005222955,0.0005504225,0.0004960338,0.001230708,0.0005094527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000579557,"about_ca_system_score_gemma":0.0003917505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008687216,"about_ca_topic_score_gemma":0.0008441818,"domain_scores_codex":[0.999397,0.0001419453,0.00002933022,0.0001755114,0.0001900646,0.00006616176],"domain_scores_gemma":[0.9995729,0.0002059027,0.00007658576,0.00003806312,0.00006525082,0.00004120167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001741606,0.000008765898,0.00008377264,0.00003799984,0.000004033415,0.00001729849,0.0000155964,0.000120469,0.9971721,0.0002741398,0.00008434003,0.00216412],"study_design_scores_gemma":[0.00001294561,0.0001489124,0.001753771,0.000008901624,0.00001516193,0.0001822744,0.00002889054,0.005610416,0.9887471,0.0003464664,0.003126879,0.00001830181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2408462,0.007112367,0.7434551,0.001011003,0.0002928213,0.0002508053,0.0006999549,0.001498102,0.004833537],"genre_scores_gemma":[0.5985076,0.008125532,0.3843133,0.0006841304,0.0001857246,0.0009332682,0.0006109208,0.0002506408,0.00638874],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0008687216,"threshold_uncertainty_score":0.004204929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863936303141054,"score_gpt":0.3099793466269342,"score_spread":0.2913399835955237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}