{"id":"W2523841505","doi":"10.1038/srep33968","title":"Bioluminescence Microscopy as a Method to Measure Single Cell Androgen Receptor Activity Heterogeneous Responses to Antiandrogens","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Biosensing Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Congressionally Directed Medical Research Programs; Fonds de Recherche du Québec - Santé; Movember Canada; Astellas Pharma; Prostate Cancer Canada; DOD Prostate Cancer Research Program; Movember Foundation; Canadian Urological Association; Université Laval","keywords":"Antiandrogens; Androgen receptor; Cell; Single-cell analysis; Population; Cell biology; Bioluminescence; Chemistry; Receptor; Biology; Prostate cancer; Internal medicine; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006537202,0.0001930339,0.0001660274,0.00009798515,0.0002595047,0.00009537916,0.0001953197,0.000122296,0.0000182626],"category_scores_gemma":[0.0002417946,0.0001498815,0.0001082055,0.0003640024,0.000120292,0.000007609825,0.0002110202,0.00003817246,0.00005994746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004178,"about_ca_system_score_gemma":0.0001253279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001235109,"about_ca_topic_score_gemma":0.00001628122,"domain_scores_codex":[0.997932,0.00008190222,0.0002611202,0.001130394,0.0002237125,0.0003708344],"domain_scores_gemma":[0.9981452,0.00001743691,0.0001506223,0.001159151,0.0002545565,0.0002729905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009401167,0.00008737845,0.0003021992,0.000003497112,0.000007594853,0.00002267567,0.00001901528,0.000002509437,0.979404,0.000001544595,0.007744522,0.01231104],"study_design_scores_gemma":[0.00005250078,0.000168261,0.00002722566,0.00002633614,0.000006598528,0.0001953936,0.000004045393,5.366937e-7,0.7560722,0.0001037996,0.2431543,0.0001888288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8952016,0.00007233836,0.102788,0.0006833464,0.0004983154,0.000535403,0.00003752819,0.0000670712,0.0001163797],"genre_scores_gemma":[0.8968606,0.000005839362,0.09827458,0.0001846607,0.00007425019,0.00004862059,0.00001894081,0.00002852928,0.004504002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2354098,"threshold_uncertainty_score":0.611199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863936303141054,"score_gpt":0.3099793466269342,"score_spread":0.2913399835955237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}