{"id":"W2523880687","doi":"10.1002/cam4.878","title":"The full blood count as a biomarker of outcome and toxicity in ipilimumab‐treated cutaneous metastatic melanoma","year":2016,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Ipilimumab; Medicine; Internal medicine; Toxicity; Gastroenterology; Lactate dehydrogenase; Melanoma; Clinical endpoint; Biomarker; Oncology; Cancer; Confidence interval; Proportional hazards model; Surgery; Clinical trial; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001562951,0.0001618491,0.0004037744,0.0006142664,0.0001538979,0.0005055033,0.0002503784,0.0002044675,0.0004709503],"category_scores_gemma":[0.003470102,0.0001594471,0.0002375685,0.0008879552,0.0002196577,0.0003286338,0.0002727274,0.000534184,0.0001079982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519765,"about_ca_system_score_gemma":0.0002275273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180518,"about_ca_topic_score_gemma":0.001603591,"domain_scores_codex":[0.9994129,0.000295002,0.00007490168,0.00006001817,0.000115844,0.00004135675],"domain_scores_gemma":[0.9974038,0.0008113045,0.001266436,0.0001044915,0.0001676107,0.0002463114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009667146,0.00003722836,0.9909733,0.00002122096,0.00005464569,0.0001720956,0.00004924614,0.0004329549,0.0007382731,0.00001793535,0.0001261199,0.006410181],"study_design_scores_gemma":[0.00001612122,0.0004033834,0.9974444,0.000007730563,0.0000247526,0.0003229455,0.0000330396,0.001268737,0.0002913193,0.00003918457,0.0001447761,0.000003484222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988102,0.0005356924,0.0002146368,0.0000432822,0.000003091194,0.000006757135,0.0001366565,0.000005101716,0.0002447224],"genre_scores_gemma":[0.9995959,0.0000979632,0.00008403917,0.00001494557,0.000005847159,0.000007141783,0.0001253528,0.000001345995,0.00006743039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562951,"threshold_uncertainty_score":0.008265793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787156978737167,"score_gpt":0.31468495001501,"score_spread":0.2868133802276384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}