{"id":"W2523885572","doi":"10.1021/acs.biochem.6b00758","title":"Reversible Covalent Binding to Cardiac Troponin C by the Ca<sup>2+</sup>-Sensitizer Levosimendan","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; Canadian Institutes of Health Research; British Heart Foundation","keywords":"Levosimendan; Contractility; Troponin; Chemistry; Cardiac muscle; Troponin C; Covalent bond; Biophysics; Troponin I; Internal medicine; Heart failure; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195911,0.0003744715,0.0002080858,0.00009633152,0.0001904395,0.0002097229,0.0004139701,0.0003782286,0.001161454],"category_scores_gemma":[0.0003111734,0.0001679592,0.0003269238,0.00007090146,0.0004761245,0.0003210813,0.0002023317,0.0004155528,0.0002129288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003825765,"about_ca_system_score_gemma":0.000181379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006206178,"about_ca_topic_score_gemma":0.0007370394,"domain_scores_codex":[0.9998747,0.00002693683,0.000007824515,0.00003239657,0.00003233351,0.0000257976],"domain_scores_gemma":[0.9998893,0.00002633592,0.00005142435,0.00001406103,0.000009503879,0.000009393639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009762309,0.0000221692,0.0004789621,0.00008076377,0.00002041851,0.0001332803,0.00002606406,0.0008160504,0.9961504,0.0005578634,0.00007426589,0.001542186],"study_design_scores_gemma":[0.00001247367,0.0001739447,0.0009713254,0.000005087942,0.00001493914,0.0001074407,0.00001157999,0.002974535,0.9945946,0.0001117437,0.001015477,0.000006775133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848917,0.001266289,0.01135452,0.0001656058,0.00004524859,0.00004802977,0.00008121036,0.00009192822,0.002055635],"genre_scores_gemma":[0.9928892,0.0006045256,0.005415438,0.00008823706,0.000007322106,0.00002521963,0.00007405948,0.00001345722,0.0008825313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161454,"threshold_uncertainty_score":0.003885448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133767141394724,"score_gpt":0.245845622478801,"score_spread":0.2345079510648538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}