{"id":"W2523966062","doi":"10.1021/acs.jmedchem.6b00938","title":"A Bone-Seeking <i>trans</i>-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using <sup>99m</sup>Tc- and <sup>177</sup>Lu-Labeled Tetrazines","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Ontario Institute for Cancer Research","keywords":"Bioorthogonal chemistry; Pretargeting; Tetrazine; Chemistry; Biodistribution; In vivo; Radiochemistry; Cyclooctene; In vitro; Combinatorial chemistry; Biochemistry; Radioimmunotherapy; Organic chemistry; Click chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160869,0.0003562864,0.0001796852,0.0001174528,0.00008578344,0.000253173,0.0002357745,0.000367254,0.0005878614],"category_scores_gemma":[0.0001240243,0.0001953892,0.0001548578,0.0001155492,0.0001737253,0.0002438166,0.0001565568,0.0004570363,0.0002320948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829244,"about_ca_system_score_gemma":0.0002365053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004995798,"about_ca_topic_score_gemma":0.0007538454,"domain_scores_codex":[0.9999044,0.00001236569,0.000004244944,0.00002155288,0.00003666271,0.00002063939],"domain_scores_gemma":[0.9999481,0.000008842415,0.00001631505,0.000003886059,0.00001037259,0.00001247318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003317736,0.0000207113,0.00002726858,0.00003668125,0.000002329221,0.00003341201,0.00001130928,0.0001147367,0.9985512,0.0001668889,0.00003086471,0.000971394],"study_design_scores_gemma":[0.00001253764,0.0002118978,0.0001443534,0.000001629279,0.000003889899,0.0001128632,0.000004646348,0.0004731703,0.9978113,0.00001560165,0.00120492,0.00000327553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525749,0.002406265,0.03873568,0.0003018371,0.00006731884,0.0002649376,0.0002535528,0.0001368543,0.005258686],"genre_scores_gemma":[0.9671102,0.001910561,0.02603396,0.0001508961,0.00001604253,0.000122816,0.0002043542,0.00002513918,0.004426199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005878614,"threshold_uncertainty_score":0.002052784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949261757502653,"score_gpt":0.3130976446649766,"score_spread":0.2836050270899501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}