{"id":"W2523966062","doi":"10.1021/acs.jmedchem.6b00938","title":"A Bone-Seeking <i>trans</i>-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using <sup>99m</sup>Tc- and <sup>177</sup>Lu-Labeled Tetrazines","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Ontario Institute for Cancer Research","keywords":"Bioorthogonal chemistry; Pretargeting; Tetrazine; Chemistry; Biodistribution; In vivo; Radiochemistry; Cyclooctene; In vitro; Combinatorial chemistry; Biochemistry; Radioimmunotherapy; Organic chemistry; Click chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008646952,0.0004018421,0.001036881,0.00005163185,0.0001538836,0.0000243333,0.0002064399,0.000243625,0.0001201469],"category_scores_gemma":[0.0008318782,0.0002837053,0.0002042261,0.0002328716,0.000557326,0.0001493307,0.00005867366,0.0005588823,9.177114e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009877758,"about_ca_system_score_gemma":0.0003144452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003334093,"about_ca_topic_score_gemma":1.154892e-7,"domain_scores_codex":[0.9970647,0.00003456701,0.001259489,0.0004660399,0.0007089916,0.0004661945],"domain_scores_gemma":[0.9973922,0.0004780118,0.000707771,0.0002796655,0.0005292398,0.0006130792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006035,0.0005760115,0.008324464,0.001863797,0.0003702446,0.000101775,0.0008071202,0.00005800496,0.9816199,0.000001059087,0.0001180278,0.005153551],"study_design_scores_gemma":[0.01358669,0.0005353856,0.0003712247,0.002393543,0.001665571,0.004016202,0.003423669,0.006841394,0.9651061,0.00008401011,0.001575764,0.0004004071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921162,0.003696698,0.00200721,0.001320926,0.00001778279,0.0005508687,0.00006606003,0.00002180904,0.0002024435],"genre_scores_gemma":[0.9964778,0.0001393826,0.00195191,0.00008739746,0.001053856,0.00002725499,0.00001083048,0.00004566397,0.0002059073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01651377,"threshold_uncertainty_score":0.9999615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949261757502653,"score_gpt":0.3130976446649766,"score_spread":0.2836050270899501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}