{"id":"W2524005613","doi":"10.1200/jco.2012.30.15_suppl.3013","title":"A phase I and pharmacokinetic (PK) study of continuous daily administration of P1446A-05, a potent and specific oral Cdk4 inhibitor.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ozmosis Research (Canada); Cancer Care Ontario; Baker Hughes (Canada)","funders":"","keywords":"Medicine; Nausea; Pharmacokinetics; Tolerability; Dosing; Pharmacodynamics; Vomiting; Pharmacology; Anorexia; Diarrhea; Internal medicine; Adverse effect; Toxicity; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009572821,0.0009796204,0.001387814,0.0003994944,0.0003553942,0.0007375073,0.0008989538,0.0008758365,0.001945621],"category_scores_gemma":[0.0008039502,0.0007024384,0.0007603832,0.0004383039,0.00116798,0.0007227847,0.0002531639,0.003049325,0.0005306671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009772875,"about_ca_system_score_gemma":0.001350746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014617,"about_ca_topic_score_gemma":0.001502156,"domain_scores_codex":[0.9996309,0.0001344183,0.00001684642,0.00008139342,0.0000584011,0.00007802695],"domain_scores_gemma":[0.9993984,0.00008611522,0.000131008,0.00007509155,0.00003297835,0.0002763804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3752123,0.1702589,0.01012015,0.0007203628,0.0008054043,0.0007099088,0.0004587535,0.005216823,0.3070173,0.0004893774,0.003946771,0.1250439],"study_design_scores_gemma":[0.1290736,0.8349161,0.01511975,0.00001584373,0.000188318,0.0006932884,0.00005518462,0.0023764,0.01490087,0.0001733403,0.00245488,0.00003244016],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955864,0.0007752716,0.0008800109,0.0001287394,0.00006589654,0.001300888,0.0004426737,0.00006493062,0.0007551849],"genre_scores_gemma":[0.9941585,0.0006295005,0.001614955,0.0001882054,0.00007545981,0.001026968,0.001076479,0.00001809533,0.001211786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945621,"threshold_uncertainty_score":0.007090807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07582525028532743,"score_gpt":0.4390781504169591,"score_spread":0.3632529001316317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}