{"id":"W2524129486","doi":"10.1182/blood.v126.23.2936.2936","title":"Insights into the Management of Adverse Events in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Experience from the Phase 3 HELIOS Study of Ibrutinib Combined with Bendamustine/Rituximab","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Ibrutinib; Bendamustine; Medicine; Internal medicine; Adverse effect; Chronic lymphocytic leukemia; Placebo; Rituximab; Ofatumumab; Oncology; Clinical endpoint; Neutropenia; Phases of clinical research; Randomized controlled trial; Lymphoma; Leukemia; Clinical trial; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00401164,0.0002656547,0.0005421721,0.0001337415,0.0002139084,0.0004365312,0.000231823,0.0002626995,0.001111014],"category_scores_gemma":[0.002389358,0.0001355265,0.0007492983,0.0001924916,0.0003381144,0.000361466,0.0003064236,0.000730816,0.0001744773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620305,"about_ca_system_score_gemma":0.0005540663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038794,"about_ca_topic_score_gemma":0.0007518546,"domain_scores_codex":[0.9989236,0.0007402171,0.00008247616,0.0000840166,0.0001065972,0.0000629962],"domain_scores_gemma":[0.998861,0.0004973451,0.0002770174,0.00008347267,0.00008131794,0.0001998929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1581877,0.01112694,0.07184672,0.001188243,0.002196494,0.0003926981,0.001070324,0.002223311,0.03203667,0.0004866272,0.002617857,0.7166265],"study_design_scores_gemma":[0.1261704,0.6186996,0.2124819,0.0004212739,0.001814934,0.002066576,0.0006150623,0.001988347,0.008687747,0.0009181604,0.02606606,0.0000699136],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820392,0.01413241,0.0007019149,0.000506226,0.00004861371,0.0002817037,0.0001798165,0.00001529115,0.00209479],"genre_scores_gemma":[0.9935431,0.003933087,0.0009029077,0.0006632052,0.0001006208,0.0002439061,0.0002304318,0.000004009102,0.0003786381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00401164,"threshold_uncertainty_score":0.02121586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903169979178118,"score_gpt":0.2684478979602277,"score_spread":0.2494161981684465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}