{"id":"W2524129486","doi":"10.1182/blood.v126.23.2936.2936","title":"Insights into the Management of Adverse Events in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Experience from the Phase 3 HELIOS Study of Ibrutinib Combined with Bendamustine/Rituximab","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Ibrutinib; Bendamustine; Medicine; Internal medicine; Adverse effect; Chronic lymphocytic leukemia; Placebo; Rituximab; Ofatumumab; Oncology; Clinical endpoint; Neutropenia; Phases of clinical research; Randomized controlled trial; Lymphoma; Leukemia; Clinical trial; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003735841,0.00056558,0.00100996,0.0002234753,0.0001393062,0.0000113946,0.0009346064,0.0001270039,0.00001986346],"category_scores_gemma":[0.00008980253,0.0002981058,0.0001038821,0.001476435,0.0004831694,0.0001688063,0.0004311664,0.0001851786,0.00001899992],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03249916,"about_ca_system_score_gemma":0.01649982,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01423652,"about_ca_topic_score_gemma":0.001892352,"domain_scores_codex":[0.9953175,0.0003416269,0.001027298,0.0008275328,0.001788117,0.000697947],"domain_scores_gemma":[0.9965525,0.000275671,0.0005152522,0.001850065,0.0004965208,0.0003099588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1396077,0.1110691,0.450139,0.004062344,0.01413886,0.004603344,0.2534277,0.00909075,0.0006527612,0.0001730622,0.0001194526,0.01291587],"study_design_scores_gemma":[0.8691595,0.01734103,0.07838605,0.00244153,0.002234591,0.00004485808,0.01741754,0.007457796,0.00492015,0.0000222839,0.0000462891,0.0005284411],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934428,0.0007925731,0.00001040821,0.00001316255,0.00006210175,0.005401469,0.00001179396,0.0000604432,0.000205249],"genre_scores_gemma":[0.9988425,0.00006857643,0.0001927616,0.00004819231,0.00004966203,0.0005224166,0.00008895827,0.00008323338,0.0001037351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7295517,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903169979178118,"score_gpt":0.2684478979602277,"score_spread":0.2494161981684465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}