{"id":"W2524153958","doi":"10.1038/srep34051","title":"Rescue of Early bace-1 and Global DNA Demethylation by S-Adenosylmethionine Reduces Amyloid Pathology and Improves Cognition in an Alzheimer’s Model","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; Illinois Department of Public Health; Alzheimer Society; Merck Canada; Consortium canadien en neurodégénérescence associée au vieillissement; GlaxoSmithKline","keywords":"DNA methylation; Alzheimer's disease; Amyloid precursor protein; Genetically modified mouse; Amyloid (mycology); Methylation; Demethylation; Dementia; Biology; DNA demethylation; Amyloid precursor protein secretase; DNA; Transgene; Disease; Medicine; Pathology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081407,0.0003938779,0.0004190039,0.000503229,0.0001226652,0.0001885111,0.0002857173,0.0002606905,0.001193631],"category_scores_gemma":[0.0001889102,0.0001734484,0.000292393,0.000161652,0.000325171,0.0001321638,0.0002399496,0.0005720219,0.0001705807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543641,"about_ca_system_score_gemma":0.0002398448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337305,"about_ca_topic_score_gemma":0.002402736,"domain_scores_codex":[0.9998823,0.00001870852,0.00001269666,0.00003281104,0.00002160097,0.00003175497],"domain_scores_gemma":[0.9998265,0.00002086886,0.00005873165,0.00003089608,0.00001528506,0.00004778758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006074372,0.0001090468,0.0005019053,0.00002445809,0.00002817252,0.00004035931,0.00002450394,0.00007280364,0.9964888,0.00005347699,0.00004538636,0.002003718],"study_design_scores_gemma":[0.00008076291,0.002040022,0.01517637,0.0000126418,0.00008565905,0.0001914715,0.00005764582,0.0009008298,0.9799024,0.0001594624,0.001383112,0.000009543657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979208,0.0004516866,0.0009910139,0.00005593073,0.00001416714,0.00001146004,0.0002114926,0.00007360423,0.0002699787],"genre_scores_gemma":[0.9964898,0.0004488657,0.001160327,0.00003404992,0.000008099298,0.00003620612,0.0004073872,0.000016918,0.001398462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337305,"threshold_uncertainty_score":0.003993154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018866166310761,"score_gpt":0.2806987312965281,"score_spread":0.2618325649857671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}