{"id":"W2524202321","doi":"10.1021/acs.jmedchem.6b00774","title":"Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Wellcome Trust","keywords":"Bromodomain; CREB-binding protein; Chemistry; Histone Acetyltransferases; Acetylation; Chromatin; Histone; BRD4; Transcription factor; Histone acetyltransferase; CREB; Transcription (linguistics); Biochemistry; Cell biology; Gene; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051431,0.0004638537,0.0003610734,0.0002072941,0.0001054305,0.0002018329,0.0004243867,0.0002219021,0.0008900567],"category_scores_gemma":[0.00009700369,0.0001582593,0.0002465561,0.0001382526,0.0001234683,0.00018012,0.0001529494,0.0006052182,0.0004143319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003610883,"about_ca_system_score_gemma":0.0002278979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007114337,"about_ca_topic_score_gemma":0.001987676,"domain_scores_codex":[0.9999361,0.000007975001,0.000003370284,0.0000129987,0.00001928768,0.00002022157],"domain_scores_gemma":[0.9999743,0.000003319476,0.000007032741,0.000002556079,0.000005213824,0.000007585909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001550236,0.0001113835,0.00009528964,0.0001201484,0.00001879361,0.0000990609,0.00002288778,0.0006701162,0.9831308,0.0003942316,0.0003478569,0.0148344],"study_design_scores_gemma":[0.0002843127,0.001573553,0.001296154,0.00001447211,0.00004949758,0.0005052594,0.00001651156,0.002826256,0.9791545,0.0001280979,0.0141355,0.00001601337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.913968,0.01467609,0.04875569,0.0006806048,0.00015551,0.00083775,0.001543498,0.0009048865,0.01847781],"genre_scores_gemma":[0.9611542,0.01289155,0.01609488,0.0002241349,0.00003430354,0.0002585943,0.001303372,0.00004465921,0.007994209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008900567,"threshold_uncertainty_score":0.00297749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007480510016960201,"score_gpt":0.2378407585657916,"score_spread":0.2303602485488314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}