{"id":"W2524552526","doi":"10.1021/acs.joc.6b01990","title":"Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Oxidative Organic Chemistry Reactions","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Partnership for Innovation and Commercialization; TDC Research; TDC Research Foundation; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Chemistry; Hydromorphone; Cycloaddition; Intramolecular force; Enantiomer; Hypervalent molecule; Total synthesis; Stereochemistry; Reagent; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001910021,0.0004402056,0.0002453938,0.0002442952,0.0001353238,0.0001967313,0.0003168928,0.0001657805,0.001550964],"category_scores_gemma":[0.000122092,0.0001410108,0.0002352029,0.0001735311,0.0002031155,0.0003096142,0.0003041835,0.0005168355,0.0005259863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647672,"about_ca_system_score_gemma":0.0004745923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003043729,"about_ca_topic_score_gemma":0.0008486963,"domain_scores_codex":[0.9998925,0.0000124656,0.00001041398,0.00002388847,0.0000296956,0.0000311233],"domain_scores_gemma":[0.9999303,0.000007761399,0.00001384879,0.00001830228,0.00001395659,0.00001593467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000793489,0.00005566619,0.0001114319,0.0001163626,0.00001142389,0.0001950428,0.00003755515,0.0003523216,0.9881925,0.0008822319,0.0001442115,0.00982184],"study_design_scores_gemma":[0.00002805489,0.0005693368,0.000718148,0.000006910203,0.00001466334,0.0003364002,0.00001405512,0.0005250738,0.991493,0.0001374911,0.006143745,0.00001313329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8970193,0.002847367,0.07699461,0.0002968604,0.0001787038,0.0005817057,0.001419282,0.0003133966,0.02034887],"genre_scores_gemma":[0.9676492,0.001728385,0.02467527,0.00007446854,0.00002234046,0.000110287,0.0004626444,0.00003456859,0.005242763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550964,"threshold_uncertainty_score":0.005188525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243548294534218,"score_gpt":0.216687085527127,"score_spread":0.2042516025817848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}