{"id":"W2524624166","doi":"10.2217/fvl-2016-0069","title":"Selective Replication of miR-145-regulated Oncolytic Adenovirus in MCF-7 Breast Cancer Cells","year":2016,"lang":"en","type":"article","venue":"Future Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tehran University of Medical Sciences and Health Services","keywords":"Oncolytic virus; Oncolytic adenovirus; Virotherapy; Viral replication; Breast cancer; Cancer research; Cancer cell; MCF-7; Biology; Cell culture; Virus; Virology; microRNA; Breast carcinoma; Titer; Cancer; Gene; Human breast; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002678479,0.0001576211,0.0002207669,0.0001243287,0.00003097048,0.000003237534,0.0002692085,0.0003614677,0.0001867551],"category_scores_gemma":[0.00002420148,0.0001189594,0.00006528548,0.0002496067,0.0001582162,0.000004401125,0.00007207115,0.0001267296,0.00002526087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007797942,"about_ca_system_score_gemma":0.0002068582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009262795,"about_ca_topic_score_gemma":0.001334374,"domain_scores_codex":[0.9985107,0.0002078403,0.0002578226,0.0005526086,0.000127664,0.0003433394],"domain_scores_gemma":[0.9989815,0.00002485131,0.00012702,0.000654808,0.0001432954,0.00006853329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003500465,0.00009562456,0.003219277,0.00001048637,0.00006339156,0.000002263746,0.00004741515,0.00003061512,0.9755242,0.00001915456,0.001510292,0.01597681],"study_design_scores_gemma":[0.001293398,0.001246499,0.0559656,0.00001307703,0.000009125016,0.00001437262,0.00001389686,0.00001603032,0.9347557,0.00007482241,0.00645201,0.000145446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959142,0.000894785,0.00005768374,0.002365666,0.000166691,0.000312107,0.0001259214,0.00001170175,0.0001512467],"genre_scores_gemma":[0.9978513,0.0006053385,0.00004180379,0.0003477384,0.0004874106,0.00008984109,0.00002738327,0.00003007195,0.0005190985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05274633,"threshold_uncertainty_score":0.4851025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008006921809513207,"score_gpt":0.286194893874184,"score_spread":0.2781879720646708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}