{"id":"W2524656042","doi":"10.1038/cddis.2016.277","title":"Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis","year":2016,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Glaucoma Research Society of Canada; Glaucoma Research Foundation","keywords":"Astrocyte; Gliosis; Cell biology; Glial fibrillary acidic protein; Biology; p38 mitogen-activated protein kinases; Neuroinflammation; Neuroglia; MAPK/ERK pathway; Kainic acid; Neuroscience; Chemistry; Glutamate receptor; Signal transduction; Inflammation; Biochemistry; Central nervous system; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538504,0.0005204607,0.0005197983,0.0003272238,0.0002094287,0.0002455841,0.000371929,0.0002739543,0.001113764],"category_scores_gemma":[0.0001477757,0.0001374123,0.0003722015,0.0002232171,0.0002762153,0.0001904805,0.0001568055,0.000952876,0.0003460769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418857,"about_ca_system_score_gemma":0.0004054949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007167623,"about_ca_topic_score_gemma":0.0013108,"domain_scores_codex":[0.9998633,0.00002293047,0.00002303001,0.00002241811,0.00002487596,0.00004340907],"domain_scores_gemma":[0.9999052,0.00001756089,0.00002818092,0.00001316034,0.00001224718,0.00002366039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009163926,0.0005568057,0.0001459549,0.0002156779,0.00004157362,0.00009856298,0.00004039828,0.0001595837,0.9905054,0.0001706513,0.0001621168,0.006986879],"study_design_scores_gemma":[0.0002204867,0.004940539,0.001998532,0.00002051013,0.00006367118,0.0002540472,0.00003726645,0.0006355823,0.9891399,0.00007622086,0.002606838,0.000006326363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896064,0.003811241,0.003324357,0.0002024326,0.0001084631,0.0001374142,0.0004385603,0.0002217449,0.002149412],"genre_scores_gemma":[0.9884678,0.005161198,0.003565733,0.00007480261,0.0000461525,0.0001814121,0.000485688,0.00002423079,0.001993064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113764,"threshold_uncertainty_score":0.003725946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780098633419586,"score_gpt":0.2476004434734062,"score_spread":0.2297994571392104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}