{"id":"W2524772133","doi":"10.1016/j.cjca.2016.07.480","title":"GLYOXYLASE 1 OVER EXPRESSION ATTENUATES THE ADVERSE EFFECTS OF CHRONIC HYPERGLYCEMIA ON THE THERAPEUTIC REGENERATION BY EXPLANT DERIVED CARDIAC STEM CELLS","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Methylglyoxal; Medicine; Diabetes mellitus; Myocardial infarction; Stem cell; Ex vivo; Regeneration (biology); Explant culture; Internal medicine; Detoxification (alternative medicine); In vivo; Cardiology; Pharmacology; Endocrinology; In vitro; Enzyme; Cell biology; Pathology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003404887,0.0001181519,0.0001989756,0.00005120067,0.0001133777,0.000006338995,0.0002840038,0.0001091094,0.00001078976],"category_scores_gemma":[0.0001253265,0.00005651081,0.0001311892,0.00005790122,0.0002215534,0.000008146947,0.00002118426,0.0001330536,0.000004774725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008942486,"about_ca_system_score_gemma":0.0005231014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000275305,"about_ca_topic_score_gemma":0.00004154956,"domain_scores_codex":[0.9987177,0.0005231858,0.000215219,0.0001660918,0.0001314695,0.0002463099],"domain_scores_gemma":[0.9989027,0.0002140198,0.0001819528,0.0003880927,0.0001759633,0.0001372863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008644884,0.000001682733,0.0002817775,0.000008232038,0.00009905524,0.000005347845,0.00003089195,0.0006917747,0.9744368,0.0000373922,0.01694864,0.007371984],"study_design_scores_gemma":[0.0003663891,0.0003666262,0.0004577692,0.00003672206,0.00002083967,0.00001693859,0.00003955185,0.000002486029,0.8709663,0.00003020125,0.1276282,0.00006805525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865605,0.006070565,0.004157001,0.002000935,0.0007206326,0.0002890417,0.00007395356,0.000001745795,0.0001256206],"genre_scores_gemma":[0.9974667,0.001345641,0.00001147108,0.0001596813,0.0006826823,0.00001410618,0.000008323376,0.00001571605,0.0002956727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106795,"threshold_uncertainty_score":0.2304444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004071235211301,"score_gpt":0.2318975384817228,"score_spread":0.2218568261296098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}