{"id":"W2525124319","doi":"10.1200/jco.2012.30.15_suppl.tps4134","title":"Dasatinib combined with gemcitabine (Gem) in patients (pts) with locally advanced pancreatic adenocarcinoma (PaCa): Design of CA180-375, a placebo-controlled, randomized, double-blind phase II trial.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Dasatinib; Medicine; Internal medicine; Gemcitabine; Phases of clinical research; Cancer; Clinical endpoint; Oncology; Gastroenterology; Clinical trial; Myeloid leukemia; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002399452,0.002214152,0.002754932,0.0006917653,0.0005168082,0.001274003,0.001019115,0.001924844,0.006636648],"category_scores_gemma":[0.001695471,0.0009753527,0.001649456,0.000652969,0.001596471,0.001389077,0.000575345,0.002530844,0.001339881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001220066,"about_ca_system_score_gemma":0.001839667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033901,"about_ca_topic_score_gemma":0.00284836,"domain_scores_codex":[0.9991181,0.0004648828,0.00005511968,0.0001767418,0.00005525742,0.0001298411],"domain_scores_gemma":[0.9992862,0.0001092438,0.0001517696,0.00006068449,0.00004191566,0.0003502026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9758263,0.01022642,0.0006081344,0.0003897338,0.0004244965,0.00003676439,0.00005163077,0.0002871914,0.002712736,0.00008335849,0.0003805851,0.008972678],"study_design_scores_gemma":[0.9123203,0.08565769,0.0007673129,0.00001333566,0.0002238353,0.00002471817,0.00001798182,0.0001708872,0.0002348606,0.00009412497,0.0004655932,0.000009399127],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9767246,0.003806083,0.0008036534,0.0009118314,0.0005597312,0.01409663,0.001074381,0.0001266834,0.001896329],"genre_scores_gemma":[0.9789995,0.002622599,0.002368505,0.001133319,0.0004571254,0.01110616,0.0007913531,0.00002137245,0.0025001],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006636648,"threshold_uncertainty_score":0.02220178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08178953788669324,"score_gpt":0.4010976613704846,"score_spread":0.3193081234837913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}