{"id":"W2525272420","doi":"10.1177/2326409816666296","title":"Integrated Multianalyte Second-Tier Testing for Newborn Screening for MSUD, IVA, and GAMT Deficiencies","year":2016,"lang":"en","type":"article","venue":"Journal of Inborn Errors of Metabolism and Screening","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Maple syrup urine disease; Screening test; Newborn screening; Chromatography; Chemistry; Computer science; Medicine; Pediatrics; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001075167,0.0002393735,0.000534891,0.0002017133,0.0001423251,0.00003402385,0.0002269242,0.0001439557,0.000008911121],"category_scores_gemma":[0.001411041,0.0001620945,0.0002028198,0.0001494211,0.000194617,0.00003408455,0.00009013375,0.00009511189,9.027519e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001631188,"about_ca_system_score_gemma":0.00008905376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002113235,"about_ca_topic_score_gemma":0.00003534449,"domain_scores_codex":[0.9984794,0.00006583852,0.0006317917,0.0002939447,0.0001932707,0.00033581],"domain_scores_gemma":[0.9982077,0.0001972016,0.000633684,0.0001794766,0.0006155231,0.0001664174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007602577,0.00003130776,0.009054432,0.0000838721,0.000246505,0.00000103037,0.0001492972,0.00009451939,0.5208322,0.00009733049,0.0008397159,0.4678096],"study_design_scores_gemma":[0.021408,0.002600146,0.2066676,0.0009614648,0.001554536,0.0002021585,0.006020199,0.004478034,0.3989504,0.001311281,0.354282,0.001564192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6740875,0.009355791,0.3159038,0.0001738965,0.0001298076,0.0001915819,0.0001063109,0.000003520691,0.00004781882],"genre_scores_gemma":[0.6921642,0.0004248757,0.3066689,0.0001213148,0.0002612947,0.00001025273,0.000008830267,0.0000326121,0.0003076632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4662454,"threshold_uncertainty_score":0.661002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317321126622369,"score_gpt":0.2677931221017646,"score_spread":0.2360610094395277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}