{"id":"W2525281696","doi":"10.1016/j.molmed.2016.09.001","title":"Targeting Single Molecules in Asthma Benefits Few","year":2016,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"","keywords":"Medicine; Mepolizumab; Asthma; Exhaled nitric oxide; Clinical trial; Bronchial thermoplasty; Dupilumab; Benralizumab; Immunology; Periostin; Omalizumab; Internal medicine; Eosinophil; Immunoglobulin E","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006131846,0.0009982712,0.001783822,0.001276239,0.0002021719,0.001038297,0.0006305051,0.001236693,0.00613485],"category_scores_gemma":[0.0007634938,0.0003147643,0.0005830303,0.000866193,0.0005586466,0.001974258,0.0009867427,0.002837175,0.002576948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004163363,"about_ca_system_score_gemma":0.0007728327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132991,"about_ca_topic_score_gemma":0.001036532,"domain_scores_codex":[0.9998105,0.00003397397,0.00002890349,0.00003576061,0.0000664506,0.00002427089],"domain_scores_gemma":[0.9997286,0.0001357927,0.00005125746,0.00001041831,0.00004506662,0.00002890117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000204668,0.00009350165,0.0001442726,0.02090023,0.0001491786,0.0001778341,0.00005144149,0.000308949,0.004231873,0.005735553,0.03554513,0.9324575],"study_design_scores_gemma":[0.00008344289,0.0001832164,0.0004959939,0.004375755,0.0003052488,0.0007070994,0.00003977625,0.0001236153,0.0009136868,0.004024778,0.9887257,0.00002172025],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001381991,0.9973112,0.000255923,0.0005383639,0.0005384568,0.000007176935,0.00001993386,0.00001243471,0.001178339],"genre_scores_gemma":[0.0011692,0.9964078,0.0002887758,0.0006109747,0.0004562759,0.00001108372,0.00002669974,0.000002606084,0.001026588],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00613485,"threshold_uncertainty_score":0.02052307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724338161289517,"score_gpt":0.3412859928523975,"score_spread":0.3040426112395023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}