{"id":"W2525281696","doi":"10.1016/j.molmed.2016.09.001","title":"Targeting Single Molecules in Asthma Benefits Few","year":2016,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval","funders":"","keywords":"Medicine; Mepolizumab; Asthma; Exhaled nitric oxide; Clinical trial; Bronchial thermoplasty; Dupilumab; Benralizumab; Immunology; Periostin; Omalizumab; Internal medicine; Eosinophil; Immunoglobulin E","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004714942,0.0008222829,0.003120709,0.002073948,0.00003667416,0.00001038353,0.000328124,0.000533902,0.001077512],"category_scores_gemma":[0.0004841009,0.00052089,0.0004947681,0.001568766,0.0002711374,0.00005079384,0.0001313042,0.0006997275,0.00008744194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003417316,"about_ca_system_score_gemma":0.0002385835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002776357,"about_ca_topic_score_gemma":0.00001504535,"domain_scores_codex":[0.995825,0.0003427974,0.001432587,0.0009267743,0.0007123378,0.0007604834],"domain_scores_gemma":[0.9982707,0.0001462671,0.0004024925,0.0007201014,0.00006945316,0.000391022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002688128,0.000230801,0.0000533471,0.003979831,0.00006556376,0.003389747,0.00004427903,0.000004155654,0.000117573,0.0001062321,0.0007118349,0.9912698],"study_design_scores_gemma":[0.002141319,0.0005341388,0.0002721597,0.07292842,0.0003719111,0.0001472881,0.00003667673,0.000006895477,0.00001710051,0.00001872057,0.9230062,0.0005191133],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001387023,0.9921255,0.000114022,0.0003944821,0.0002668854,0.0004828797,0.00002961281,0.00007942227,0.00636856],"genre_scores_gemma":[0.0003391116,0.996839,0.0003213476,0.0004834677,0.0005385167,0.0001209126,0.0004079328,0.0001818411,0.000767849],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907507,"threshold_uncertainty_score":0.9998356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03724338161289517,"score_gpt":0.3412859928523975,"score_spread":0.3040426112395023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}