{"id":"W2525396082","doi":"10.1021/acsinfecdis.6b00143","title":"Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap","year":2016,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"NS5B; Cyclophilin A; Cypa; NS5A; RNA; Cyclophilin; Biology; RNA-dependent RNA polymerase; RNA polymerase; RNA-binding protein; Hepatitis C virus; Chemistry; Molecular biology; Biochemistry; Virology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008978955,0.000195576,0.0001012699,0.0001159603,0.000162335,0.0001367494,0.0001332271,0.0001049619,0.0008851941],"category_scores_gemma":[0.00009071015,0.00008252313,0.0001918137,0.00009045222,0.000120127,0.0000936252,0.0001460526,0.0001454187,0.0001840266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246881,"about_ca_system_score_gemma":0.00008158449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007059718,"about_ca_topic_score_gemma":0.0008997207,"domain_scores_codex":[0.9999136,0.00001617561,0.000003972943,0.00001793659,0.00002925329,0.00001914873],"domain_scores_gemma":[0.999949,0.0000105126,0.00001461979,0.00000526889,0.000005775931,0.00001487048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174562,0.00002090466,0.00202761,0.00003448552,0.00001607276,0.00008272488,0.00002378631,0.000168236,0.9956617,0.000229033,0.00004915766,0.001511853],"study_design_scores_gemma":[0.00001703211,0.0002252177,0.07760928,0.00001076573,0.00003845643,0.0006742089,0.00009204513,0.007462794,0.9103067,0.0002670113,0.00328701,0.000009542255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978207,0.0004563059,0.0009330997,0.00001639576,0.000004090525,0.000003129523,0.00005075377,0.000007654872,0.0007078924],"genre_scores_gemma":[0.9989432,0.00009533925,0.0004271656,0.00001317159,0.000001299975,0.000002623817,0.0001272516,0.000002134597,0.0003878521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008851941,"threshold_uncertainty_score":0.002961278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00870447378762889,"score_gpt":0.2692279815405906,"score_spread":0.2605235077529617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}