{"id":"W2525525075","doi":"10.1182/blood.v120.21.lba-6.lba-6","title":"Pomalidomide in Combination with Low-Dose Dexamethasone: Demonstrates a Significant Progression Free Survival and Overall Survival Advantage, in Relapsed/Refractory MM: A Phase 3, Multicenter, Randomized, Open-Label Study","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Pomalidomide; Medicine; Lenalidomide; Thalidomide; Internal medicine; Population; Dexamethasone; Refractory (planetary science); Progression-free survival; Interim analysis; Phases of clinical research; Bortezomib; Surgery; Multiple myeloma; Intention-to-treat analysis; Neutropenia; Gastroenterology; Randomized controlled trial; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002369863,0.001789097,0.00249544,0.0004763628,0.0004883442,0.001548391,0.001380449,0.001563331,0.00439715],"category_scores_gemma":[0.001236131,0.0007702481,0.001969869,0.0005895419,0.001483655,0.001239902,0.0005247846,0.004301418,0.0008424364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009432309,"about_ca_system_score_gemma":0.001367164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007732121,"about_ca_topic_score_gemma":0.001974873,"domain_scores_codex":[0.9992663,0.0004191733,0.00004888041,0.0001169134,0.00006155953,0.00008718356],"domain_scores_gemma":[0.9987912,0.0002594474,0.0002909783,0.00009890459,0.00004206701,0.0005174358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9464723,0.02453344,0.001594255,0.0003011786,0.0007369158,0.00006002263,0.00007013509,0.0003150235,0.008575825,0.00006692548,0.000705275,0.01656877],"study_design_scores_gemma":[0.8076271,0.1862932,0.003656519,0.00002311197,0.0004466931,0.00007481641,0.00003046056,0.0003919834,0.0008890236,0.00008995958,0.0004579338,0.00001924215],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995048,0.002045751,0.0001996181,0.0003819613,0.000145859,0.0009390166,0.0005391879,0.00005550558,0.0006450078],"genre_scores_gemma":[0.9944958,0.001395649,0.0007442765,0.0006653359,0.0003054161,0.0009116384,0.0006229829,0.00001899531,0.0008399728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00439715,"threshold_uncertainty_score":0.01470995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03688351435222334,"score_gpt":0.3623769974216015,"score_spread":0.3254934830693782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}