{"id":"W2525582001","doi":"10.1074/jbc.m116.756437","title":"A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC)","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Epithelial sodium channel; Cytosol; Ion channel; Transmembrane channels; Transmembrane domain; Biophysics; Chemistry; Protein subunit; Extracellular; Transmembrane protein; Biochemistry; Acid-sensing ion channel; Cytoplasm; Cell biology; Biology; Membrane; Voltage-gated ion channel; Receptor; Sodium; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003158307,0.0001374616,0.0002178596,0.000009995339,0.00007211939,0.000005544749,0.0002597142,0.0002402122,0.00002606618],"category_scores_gemma":[0.0001868441,0.00005305128,0.0003281579,0.00007486249,0.0002906315,0.000005531486,0.00005296562,0.000139952,0.000001078836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001982846,"about_ca_system_score_gemma":0.00006110957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001940895,"about_ca_topic_score_gemma":0.000001395396,"domain_scores_codex":[0.9991307,0.00007811436,0.0002964445,0.0001534601,0.0001692011,0.0001720535],"domain_scores_gemma":[0.9990029,0.00005164955,0.000449429,0.0002281291,0.0002088692,0.00005905524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003766949,0.00006463691,0.0007865825,0.000008672338,0.00005414684,0.000002077374,0.00001882267,0.000007940806,0.997507,0.000009021858,0.0001150789,0.001049261],"study_design_scores_gemma":[0.0006724462,0.0001842482,0.01554162,0.00004538636,0.000022411,0.00007286235,0.000045939,0.000004537912,0.9817712,0.0001974865,0.001357316,0.0000845633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965716,0.0002481848,0.0008462131,0.001941736,0.0001311379,0.0000913148,0.00002951767,0.000003244888,0.0001370219],"genre_scores_gemma":[0.9988497,0.000202515,0.000008704283,0.0001219577,0.0006504861,0.000004084554,0.000004605606,0.000006881377,0.000151056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01573589,"threshold_uncertainty_score":0.2163369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560587376639743,"score_gpt":0.2264375109856673,"score_spread":0.2108316372192698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}