{"id":"W2525618658","doi":"10.1021/acs.est.6b03541","title":"An Unbiased Chemical Proteomics Method Identifies FabI as the Primary Target of 6-OH-BDE-47","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Proteomics; Small molecule; Enzyme; Chemistry; Chemical biology; Biochemistry; Escherichia coli; In vivo; Primary (astronomy); Drug discovery; Polybrominated diphenyl ethers; Mechanism of action; Ligand (biochemistry); Target protein; High-throughput screening; Computational biology; In vitro; Biology; Receptor; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004231502,0.0006175967,0.0004133724,0.000470872,0.0002818601,0.0002995092,0.0003019791,0.000470668,0.0006959073],"category_scores_gemma":[0.0003562574,0.0002632444,0.0003585759,0.0003215018,0.0003367263,0.0002635975,0.0003525393,0.0005917157,0.0007483941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004071459,"about_ca_system_score_gemma":0.0003667802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005965613,"about_ca_topic_score_gemma":0.001641199,"domain_scores_codex":[0.9994695,0.00005785036,0.00002673852,0.0001482275,0.0002229185,0.00007492027],"domain_scores_gemma":[0.9997997,0.00004159184,0.00005462131,0.00002222517,0.00005884107,0.00002309008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009268612,0.000004704138,0.0001208592,0.00001845389,0.000003222428,0.00000785103,0.000005382848,0.00002048254,0.9990228,0.00003838756,0.00001907579,0.0007294908],"study_design_scores_gemma":[0.000001565502,0.00003731028,0.0009449735,0.000001644715,0.000006290361,0.00004858861,0.000008182674,0.0004023444,0.997906,0.00002164828,0.0006187945,0.000002690435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7200747,0.003906008,0.2685819,0.0004513386,0.0001258109,0.000272776,0.001890628,0.0007920103,0.003904854],"genre_scores_gemma":[0.849208,0.003583045,0.1372628,0.00041689,0.00003925609,0.000282666,0.002339932,0.0001240299,0.006743353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006959073,"threshold_uncertainty_score":0.002954066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006063020783656554,"score_gpt":0.2538633551588897,"score_spread":0.2478003343752331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}