{"id":"W2525713139","doi":"10.1016/s1474-4422(16)30203-4","title":"DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study","year":2016,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Parkinson's UK","keywords":"LRRK2; Parkinsonism; Genetics; Medicine; Genome-wide association study; Penetrance; Disease; Age of onset; Parkinson's disease; Single-nucleotide polymorphism; Biology; Genotype; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006246855,0.0008143178,0.0005667214,0.001073821,0.0007868216,0.0006963355,0.0006912375,0.001285033,0.003569664],"category_scores_gemma":[0.001270917,0.0004219446,0.001201983,0.001592256,0.0003834212,0.0003793403,0.0006589881,0.0007584029,0.0003108703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004501988,"about_ca_system_score_gemma":0.000282997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007260413,"about_ca_topic_score_gemma":0.007963434,"domain_scores_codex":[0.9995833,0.0001018873,0.00005311065,0.0001320557,0.00006721324,0.00006235172],"domain_scores_gemma":[0.9994243,0.0001637542,0.0002320409,0.00004652171,0.00004698886,0.00008642509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00752168,0.0003072851,0.9526935,0.00008298736,0.001832908,0.005081247,0.0004900723,0.0004966977,0.02202835,0.0004572529,0.0006124146,0.008395691],"study_design_scores_gemma":[0.0001605743,0.0002310029,0.9932982,0.00002281004,0.000742604,0.00275833,0.0002063489,0.000816635,0.0008568368,0.0003343466,0.0005503436,0.00002182981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982283,0.0005448459,0.0001957142,0.0001120981,0.00001310761,0.000005864819,0.0004085967,0.00001040174,0.00048117],"genre_scores_gemma":[0.9990618,0.0001169593,0.0001936995,0.00003410738,0.00001301375,0.000005454293,0.0001800645,0.00000612345,0.0003888649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007260413,"threshold_uncertainty_score":0.0144363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209802777819515,"score_gpt":0.2619077192361424,"score_spread":0.2398096914579472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}