{"id":"W2525713139","doi":"10.1016/s1474-4422(16)30203-4","title":"DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study","year":2016,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Parkinson's UK","keywords":"LRRK2; Parkinsonism; Genetics; Medicine; Genome-wide association study; Penetrance; Disease; Age of onset; Parkinson's disease; Single-nucleotide polymorphism; Biology; Genotype; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162109,0.00007046304,0.0002937838,0.00005367417,0.00001447029,0.000001884893,0.00004800207,0.00005110405,0.000008313104],"category_scores_gemma":[0.00007846043,0.00004053384,0.0000180996,0.00004694154,0.00004518939,0.00001263627,0.00003583124,0.00006581123,0.000001641288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001093643,"about_ca_system_score_gemma":0.00001475737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004259815,"about_ca_topic_score_gemma":0.00005170963,"domain_scores_codex":[0.9993562,0.0001312515,0.0001349483,0.0001470812,0.00009019273,0.0001403398],"domain_scores_gemma":[0.9995086,0.0001661464,0.00009243541,0.0001835935,0.00001575302,0.00003352503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003952542,0.0001481369,0.9951061,0.00001560601,0.00006535312,0.0001328126,0.0002645027,0.000001070246,0.002778244,0.0000170306,0.00006412942,0.001011753],"study_design_scores_gemma":[0.003014202,0.0006063763,0.9939322,0.000006799257,0.00007057974,0.0000103808,0.00001030098,0.00001080064,0.0001494345,0.000991536,0.001164836,0.0000325096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976953,0.0002851927,0.00001932817,0.001535917,0.00003514978,0.0002832486,0.00002834444,0.000009583041,0.0001079387],"genre_scores_gemma":[0.9989216,0.0003559456,0.00004393623,0.000551759,0.00002584345,0.00002059014,0.000002835048,0.000008002863,0.00006949712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00262881,"threshold_uncertainty_score":0.1652922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209802777819515,"score_gpt":0.2619077192361424,"score_spread":0.2398096914579472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}