{"id":"W2525729338","doi":"10.1128/jvi.00748-16","title":"RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; McGill University","keywords":"Biology; Sting; Innate immune system; STAT1; Stimulator of interferon genes; Herpes simplex virus; Autocrine signalling; IRF3; Cell biology; Signal transduction; RIG-I; Immune system; Downregulation and upregulation; Paracrine signalling; Tumor necrosis factor alpha; Immunology; Virus; Cell culture; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576194,0.0004356246,0.000201649,0.0001956294,0.0001392535,0.0003989057,0.0002310689,0.000241047,0.003776696],"category_scores_gemma":[0.0001605447,0.00008285098,0.0002742211,0.0001279822,0.0003115875,0.0002268411,0.0002921609,0.0004772118,0.001384025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003329361,"about_ca_system_score_gemma":0.000224879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000185129,"about_ca_topic_score_gemma":0.0002907407,"domain_scores_codex":[0.9998131,0.00003224345,0.00001946576,0.00003039496,0.00004220961,0.00006257201],"domain_scores_gemma":[0.9998854,0.00002274563,0.00003578769,0.00001672955,0.00001266248,0.00002666105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001592652,0.00001899356,0.0001566986,0.00008147366,0.000002108873,0.00003939688,0.000012724,0.00004931854,0.9974171,0.00007534213,0.00005804486,0.001929541],"study_design_scores_gemma":[0.00001321231,0.0003563608,0.00352883,0.00002506615,0.00001465658,0.0002931014,0.0000375585,0.0006906907,0.990893,0.00005515643,0.004087766,0.000004540193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667358,0.01459663,0.008161598,0.0001864912,0.0001998347,0.00009931034,0.0010417,0.0004207277,0.008558013],"genre_scores_gemma":[0.9923838,0.002010424,0.002579441,0.00006100863,0.00004198812,0.00004373862,0.0005942592,0.00002400533,0.0022615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003776696,"threshold_uncertainty_score":0.01263434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528166035868633,"score_gpt":0.2555825010349476,"score_spread":0.2403008406762612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}