{"id":"W2525729338","doi":"10.1128/jvi.00748-16","title":"RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; McGill University","keywords":"Biology; Sting; Innate immune system; STAT1; Stimulator of interferon genes; Herpes simplex virus; Autocrine signalling; IRF3; Cell biology; Signal transduction; RIG-I; Immune system; Downregulation and upregulation; Paracrine signalling; Tumor necrosis factor alpha; Immunology; Virus; Cell culture; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004456212,0.0001222601,0.0002852688,0.00027982,0.00009715313,0.000007535642,0.0001257876,0.0002940985,0.0008191364],"category_scores_gemma":[0.0008662497,0.00007678594,0.0001168618,0.00009814899,0.0001587446,0.0001938743,0.00004187872,0.0002024015,0.0003552288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006556304,"about_ca_system_score_gemma":0.00007959502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006016498,"about_ca_topic_score_gemma":0.00003030454,"domain_scores_codex":[0.9985168,0.0005319197,0.0005402064,0.0001130577,0.00003708917,0.0002609303],"domain_scores_gemma":[0.9985347,0.0006433299,0.0005126955,0.0001252087,0.0001611331,0.00002294178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001425668,0.00008905365,0.00232685,0.000003089551,0.0001393826,0.00001224737,0.00008301264,0.000006312777,0.9342996,0.0001301155,0.003241418,0.05824327],"study_design_scores_gemma":[0.003744941,0.002033165,0.2259135,0.00007705255,0.00007102132,0.001032828,0.00003049675,0.000006804748,0.4423659,0.0005277395,0.3240203,0.0001762484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948663,0.0008014367,0.001824322,0.0008462565,0.001294784,0.00005822556,0.000007026533,0.00002589878,0.0002757139],"genre_scores_gemma":[0.9983656,0.0004358141,0.0000336777,0.0001895215,0.0001100189,0.000001555609,0.000004884575,0.00001189148,0.0008470301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4919337,"threshold_uncertainty_score":0.896897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528166035868633,"score_gpt":0.2555825010349476,"score_spread":0.2403008406762612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}