{"id":"W2525758480","doi":"10.1182/blood-2016-03-703454","title":"Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"European Hematology Association","keywords":"GLI1; Hedgehog; Hedgehog signaling pathway; Transcription factor; Biology; Cancer research; Smoothened; In vivo; Gene; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285078,0.0001571624,0.000211911,0.0003155738,0.00008922665,0.0002297701,0.00008908848,0.0001417876,0.0008842718],"category_scores_gemma":[0.0001277326,0.0001072223,0.0001348335,0.0003100933,0.0001153763,0.000092972,0.00008535082,0.0002872534,0.0002376375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903269,"about_ca_system_score_gemma":0.0001664557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000683434,"about_ca_topic_score_gemma":0.00099287,"domain_scores_codex":[0.9999095,0.00002328874,0.000006963746,0.00001394028,0.00002399549,0.00002240511],"domain_scores_gemma":[0.9999565,0.00000808632,0.00001247882,0.000002857946,0.000004507842,0.0000155016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003624181,0.0001610043,0.0396122,0.00009527377,0.00004964294,0.0005706224,0.00005364708,0.000404712,0.9377488,0.000171527,0.0003135048,0.0171949],"study_design_scores_gemma":[0.0001779651,0.00222617,0.3847396,0.00001216996,0.0001438756,0.003185236,0.0001159592,0.00336984,0.601113,0.0002749229,0.004630845,0.00001050942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995635,0.001536901,0.0005464874,0.00006783465,0.000008174609,0.00002928018,0.0003871427,0.00005460917,0.001734647],"genre_scores_gemma":[0.9978426,0.000639774,0.0004776101,0.00002988763,0.00000410865,0.0000224502,0.0003755732,0.000006820894,0.0006011688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008842718,"threshold_uncertainty_score":0.002958179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006781317514613858,"score_gpt":0.2119062086239426,"score_spread":0.2051248911093287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}