{"id":"W2525803372","doi":"10.1182/blood.v104.11.1359.1359","title":"Mutator Genes UDG and AID Appear To Be Normal in Class-Switch Deficient and Clonally Homogeneous Waldenstrom’s Macroglobulinemias Having Either Germline or Hypermutated Clonotypic IgH VDJ.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Somatic hypermutation; Biology; Germline; Immunoglobulin class switching; Molecular biology; Activation-induced (cytidine) deaminase; Cytidine deaminase; Genetics; clone (Java method); Mutation; Gene rearrangement; Germline mutation; Transversion; Point mutation; IGHV@; Immunoglobulin heavy chain; Gene; B cell; Antibody; Chronic lymphocytic leukemia; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290972,0.0002326063,0.0001585502,0.0005835471,0.0001292115,0.0002153414,0.0001540101,0.000265825,0.001039519],"category_scores_gemma":[0.0005745945,0.0001376394,0.00009376906,0.0001770325,0.0002324533,0.0001127564,0.0001312214,0.0001808713,0.0001791313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301363,"about_ca_system_score_gemma":0.00007483253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004260245,"about_ca_topic_score_gemma":0.0004128945,"domain_scores_codex":[0.9998311,0.0000241147,0.00002361221,0.00004413853,0.00003357578,0.00004338921],"domain_scores_gemma":[0.999757,0.00006972987,0.00007056676,0.00001982788,0.00002606713,0.00005682606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00077023,0.000056238,0.12493,0.00006408754,0.00003102377,0.00315758,0.0002229472,0.0001160129,0.8601401,0.0001505753,0.00006415303,0.01029703],"study_design_scores_gemma":[0.00006443094,0.0009968497,0.7690973,0.00002188522,0.00008361793,0.0313437,0.0003260083,0.0008958313,0.1949425,0.0002030559,0.002014177,0.00001055736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993149,0.0002383349,0.0001452042,0.000006720015,0.00000170619,0.000002635298,0.00004478056,0.000007588865,0.0002381592],"genre_scores_gemma":[0.9996215,0.00004795819,0.000114238,0.000005812998,0.000001432928,0.00000314282,0.00008377932,0.000002460376,0.0001196334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039519,"threshold_uncertainty_score":0.003477514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808945376046048,"score_gpt":0.2744380265701668,"score_spread":0.2563485728097063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}