{"id":"W2525930159","doi":"10.1111/cbdd.12874","title":"Structure–activity relationship of caffeic acid phenethyl ester analogs as new 5‐lipoxygenase inhibitors","year":2016,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Bee Products Chemical Analysis","field":"Agricultural and Biological Sciences","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; New Brunswick Innovation Foundation; Canada Foundation for Innovation","keywords":"Caffeic acid phenethyl ester; Chemistry; Lipoxygenase; Arachidonate 5-lipoxygenase; Caffeic acid; Biochemistry; Enzyme; Structure–activity relationship; Stereochemistry; Antioxidant; In vitro; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555083,0.0003922448,0.0003222088,0.0002922698,0.0001084746,0.0001710162,0.0002331132,0.0002023815,0.001481296],"category_scores_gemma":[0.0001290374,0.0001128266,0.0002678886,0.0002278559,0.0001221952,0.0002039136,0.000146715,0.0002973452,0.0002615479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739404,"about_ca_system_score_gemma":0.0001362336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005718226,"about_ca_topic_score_gemma":0.00151068,"domain_scores_codex":[0.9999506,0.000009820766,0.000005715611,0.000008888728,0.00001165143,0.00001320541],"domain_scores_gemma":[0.9999453,0.000007223531,0.00001654284,0.000004062128,0.00001011325,0.00001673363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006145692,0.0003289652,0.000505991,0.0003933355,0.00005897982,0.00026768,0.00004167008,0.001419743,0.9844331,0.0002066229,0.0001942587,0.01153512],"study_design_scores_gemma":[0.0003645636,0.01118447,0.00977498,0.00005118432,0.0002514824,0.0006042913,0.00005436091,0.002694679,0.9610727,0.000111519,0.01379674,0.00003905978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747174,0.01862867,0.001843019,0.0001462699,0.00004573124,0.0001676446,0.0005339673,0.00005147624,0.003865743],"genre_scores_gemma":[0.9870498,0.008263492,0.002009093,0.00009412495,0.00002004506,0.00004750209,0.0005552702,0.000006567913,0.001954134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481296,"threshold_uncertainty_score":0.004955411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385776604622652,"score_gpt":0.2275787373215529,"score_spread":0.2037209712753264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}