{"id":"W2525930159","doi":"10.1111/cbdd.12874","title":"Structure–activity relationship of caffeic acid phenethyl ester analogs as new 5‐lipoxygenase inhibitors","year":2016,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Bee Products Chemical Analysis","field":"Agricultural and Biological Sciences","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; New Brunswick Innovation Foundation; Canada Foundation for Innovation","keywords":"Caffeic acid phenethyl ester; Chemistry; Lipoxygenase; Arachidonate 5-lipoxygenase; Caffeic acid; Biochemistry; Enzyme; Structure–activity relationship; Stereochemistry; Antioxidant; In vitro; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683669,0.0002830845,0.0004444435,0.00002874246,0.00008034804,0.00001414592,0.0004509568,0.0003710038,0.0009034072],"category_scores_gemma":[0.001208434,0.00009692504,0.0002093946,0.0005536375,0.0004099982,0.0001336222,0.0001415593,0.0002304228,0.0000951379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006221097,"about_ca_system_score_gemma":0.00004776996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246077,"about_ca_topic_score_gemma":0.00003518104,"domain_scores_codex":[0.9980368,0.0002496842,0.0003984065,0.000705725,0.0001735365,0.0004358693],"domain_scores_gemma":[0.9980195,0.001106104,0.0002340706,0.0001937202,0.0001030623,0.0003435673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008590786,0.00005565444,0.00766338,0.000004110542,0.00004275785,0.000001172398,0.00002993813,5.332386e-7,0.9455372,0.0001124941,0.002666255,0.04380056],"study_design_scores_gemma":[0.0002283778,0.00006855505,0.002951872,0.00001829267,0.00005597921,0.000005302009,0.00001038486,0.000003755369,0.9791911,0.01637877,0.0008337821,0.0002538532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912125,0.0003367294,0.0001474659,0.007826119,0.00009163523,0.0001790859,0.00004886179,0.00007573033,0.00008182257],"genre_scores_gemma":[0.9980102,0.00001981824,0.0007795924,0.0002433706,0.0004505357,0.00000780386,0.00005103858,0.000002866867,0.0004347406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04354671,"threshold_uncertainty_score":0.9891676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385776604622652,"score_gpt":0.2275787373215529,"score_spread":0.2037209712753264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}