{"id":"W2526013154","doi":"10.1074/mcp.m116.060483","title":"Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands","year":2016,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Sigrid Juséliuksen Säätiö; Academy of Finland; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto","keywords":"SH3 domain; Computational biology; Proto-oncogene tyrosine-protein kinase Src; Homology (biology); Chemistry; Biochemistry; Biology; Amino acid; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003847439,0.0003233532,0.0003246691,0.0002256449,0.0002019726,0.0002534319,0.0002248702,0.0002162377,0.000541842],"category_scores_gemma":[0.0003312107,0.0001460527,0.0001687946,0.0002991391,0.0001130635,0.0001201931,0.000292303,0.0002729662,0.000237901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550692,"about_ca_system_score_gemma":0.0001762818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133661,"about_ca_topic_score_gemma":0.001242882,"domain_scores_codex":[0.9997339,0.00006680093,0.00001692885,0.00004673991,0.00009429312,0.00004142444],"domain_scores_gemma":[0.9998841,0.0000559159,0.00001302887,0.00001130442,0.00001407008,0.00002152221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007796311,0.00004348082,0.0006941494,0.00001829704,0.000007852457,0.00003212263,0.00001378914,0.0002991486,0.9975478,0.00003547218,0.00002960286,0.00120028],"study_design_scores_gemma":[0.00001578604,0.0004351948,0.007086932,0.000002831756,0.00002393782,0.0002576708,0.00003746021,0.004394071,0.9867907,0.00006079695,0.0008868343,0.000007883704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927706,0.0003397291,0.006172393,0.0000262424,0.000002405851,0.00004167284,0.0002178263,0.00004552526,0.0003836452],"genre_scores_gemma":[0.9838595,0.0005413758,0.01353285,0.00005136707,0.00000433667,0.00006115345,0.0009961919,0.00001645531,0.0009366651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006133661,"threshold_uncertainty_score":0.002034783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150740629221532,"score_gpt":0.3246337313780069,"score_spread":0.2931263250857916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}