{"id":"W2526013154","doi":"10.1074/mcp.m116.060483","title":"Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands","year":2016,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Sigrid Juséliuksen Säätiö; Academy of Finland; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto","keywords":"SH3 domain; Computational biology; Proto-oncogene tyrosine-protein kinase Src; Homology (biology); Chemistry; Biochemistry; Biology; Amino acid; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005143713,0.0002787765,0.0006218891,0.0002991031,0.0001909118,0.00001211795,0.0002581161,0.0001860131,0.0002551209],"category_scores_gemma":[0.0002191441,0.0002108244,0.0003394699,0.0003123546,0.0003794401,0.0001117766,0.0002952277,0.0004089306,0.00001254145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009231041,"about_ca_system_score_gemma":0.0002369803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002550733,"about_ca_topic_score_gemma":0.00002917544,"domain_scores_codex":[0.9977124,0.0001714525,0.000618914,0.0004275235,0.000565876,0.0005038339],"domain_scores_gemma":[0.9984407,0.00006922222,0.0003448761,0.0004933199,0.000441682,0.0002101767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005791519,0.0005139315,0.00351789,0.0002135455,0.0002782824,0.0001314861,0.0006270707,0.00002164785,0.9926327,0.00126465,0.00001925323,0.0002003877],"study_design_scores_gemma":[0.001858673,0.0008407409,0.0008954642,0.0004884837,0.00009645714,0.00007393879,0.0002074939,0.0006172408,0.9924181,0.001771397,0.0005133619,0.0002186808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9271357,0.0001947353,0.06919882,0.0004345438,0.0000557259,0.001394928,0.000124905,0.00003105036,0.001429569],"genre_scores_gemma":[0.9648055,0.00001906452,0.03355956,0.0000614005,0.000085479,0.00006453792,0.00006640051,0.0000523364,0.001285672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03766983,"threshold_uncertainty_score":0.859717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150740629221532,"score_gpt":0.3246337313780069,"score_spread":0.2931263250857916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}