{"id":"W2526015823","doi":"10.1016/j.bbrep.2016.09.012","title":"A 3D-psoriatic skin model for dermatological testing: The impact of culture conditions","year":2016,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement; Université Laval","funders":"Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Psoriasis; Stratum corneum; Medicine; Drug; Dermatology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410691,0.00017185,0.0001922834,0.00001065031,0.0001836229,0.000006971098,0.0001026319,0.000201214,0.00003364213],"category_scores_gemma":[0.0001592522,0.00008870928,0.0001254229,0.00008646276,0.0003929338,0.00005798934,0.00004244151,0.000150938,0.000001160128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003000919,"about_ca_system_score_gemma":0.00009718199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002620249,"about_ca_topic_score_gemma":1.116999e-7,"domain_scores_codex":[0.9990842,0.0000332636,0.0003142331,0.0002528314,0.00008523529,0.0002302401],"domain_scores_gemma":[0.9990104,0.0002902685,0.0002495349,0.0001975914,0.0001602162,0.00009193425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009371157,0.0002666543,0.002394174,0.00009362397,0.0001903924,0.0000284841,0.0001343834,0.0008102252,0.9888716,0.0001399693,0.00182598,0.005150829],"study_design_scores_gemma":[0.001117417,0.0001197016,0.0008817175,0.00006473107,0.000276385,0.0003958381,0.00004549522,0.02919764,0.9539521,0.01279586,0.0008103228,0.0003427737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991509,0.0002624539,0.006649162,0.0001787839,0.0001233121,0.0003477167,0.0003614608,0.00003457337,0.0005335431],"genre_scores_gemma":[0.9983895,0.00008427326,0.0007577828,0.0001071408,0.0001139528,0.00007399493,0.00003705367,0.000009494688,0.0004267689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03491946,"threshold_uncertainty_score":0.361746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006749582543026,"score_gpt":0.4284435021992515,"score_spread":0.327768543944949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}