{"id":"W2526035417","doi":"10.1016/j.jalz.2016.08.010","title":"Longitudinal brain structural changes in preclinical Alzheimer's disease","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; European Regional Development Fund; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Institute of Biomedical Imaging and Bioengineering; Northern California Institute for Research and Education; Foundation for the National Institutes of Health; U.S. Department of Defense","keywords":"Atrophy; Precuneus; Biomarker; Cerebrospinal fluid; Medicine; Pathology; Cohort; Alzheimer's disease; Internal medicine; Imaging biomarker; Oncology; Disease; Magnetic resonance imaging; Cognition; Biology; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00105449,0.0002225419,0.0001925718,0.0007331846,0.0003103403,0.0004219822,0.0001990138,0.0002806636,0.0008343887],"category_scores_gemma":[0.001979728,0.0001398074,0.000196628,0.0004249312,0.0001476056,0.0003501235,0.0002913737,0.0003358336,0.0001937616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912634,"about_ca_system_score_gemma":0.0003443612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004333423,"about_ca_topic_score_gemma":0.004653473,"domain_scores_codex":[0.9998339,0.00005267025,0.00001347747,0.00003846124,0.00003255993,0.00002894328],"domain_scores_gemma":[0.9992047,0.00008971413,0.0003262447,0.00005801651,0.0001981474,0.0001231431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001376724,0.0001231641,0.9828268,0.00003395075,0.0001475298,0.0001412487,0.0001579663,0.0002354733,0.004354397,0.0000586844,0.0003516284,0.01019253],"study_design_scores_gemma":[0.000009182504,0.0002976751,0.9985799,0.000008127314,0.00003039849,0.0001990524,0.00003394099,0.0001271002,0.0004144077,0.00005563479,0.0002421072,0.000002520699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973583,0.001142225,0.0001751422,0.00006115351,0.000005238342,0.00001141345,0.0005854017,0.00001025697,0.0006508571],"genre_scores_gemma":[0.9987178,0.0002451971,0.00015756,0.00001765909,0.000008274287,0.00001048222,0.0006020014,0.000001404458,0.0002396128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004333423,"threshold_uncertainty_score":0.008616447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0652243432972268,"score_gpt":0.3732788556170683,"score_spread":0.3080545123198415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}