{"id":"W2526128409","doi":"10.1126/science.aaf8430","title":"<i>Drosophila</i> insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"European Research Council; Canadian Institutes of Health Research; Division of Arctic Sciences; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Labex; Agence Nationale de la Recherche","keywords":"Insulin; Adipose tissue; Biology; Insulin receptor; Receptor; Endocrinology; Internal medicine; Cell biology; Biochemistry; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005569016,0.0002016532,0.0001546247,0.00010148,0.0001578895,0.0002576266,0.0001628794,0.0001618201,0.001430147],"category_scores_gemma":[0.00006285754,0.00009769211,0.0001897453,0.00005394232,0.0001679723,0.0002016418,0.0002496368,0.0003988424,0.0003819836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590954,"about_ca_system_score_gemma":0.000074011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004963256,"about_ca_topic_score_gemma":0.00157388,"domain_scores_codex":[0.9999361,0.000006354388,0.000006637695,0.00002138971,0.00001263474,0.00001679536],"domain_scores_gemma":[0.9999391,0.000005916731,0.00002657984,0.000005775444,0.00000460268,0.00001797517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006017735,0.000002641629,0.0002302499,0.00001597975,0.000001936182,0.00007348879,0.000006241597,0.00001260741,0.9989702,0.00007286169,0.00005883113,0.0004948482],"study_design_scores_gemma":[0.00001841644,0.0001025257,0.02442725,0.000009337145,0.00001014373,0.0004349844,0.00005060956,0.0007847301,0.9705344,0.00005763076,0.003563081,0.00000686752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922179,0.001556823,0.001893509,0.0001854822,0.00004061074,0.00001431811,0.0006300922,0.00009761344,0.003363743],"genre_scores_gemma":[0.9914841,0.0007648055,0.002515747,0.0002052105,0.00002026105,0.0000294497,0.0009565323,0.00004469582,0.003979255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430147,"threshold_uncertainty_score":0.004784346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795615869947651,"score_gpt":0.3085271206124088,"score_spread":0.2805709619129323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}