{"id":"W2526145362","doi":"10.3389/fgene.2016.00177","title":"Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging","year":2016,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Biology; Saccharomyces cerevisiae; Organelle; Cell biology; Yeast; Mitochondrion; Cytosol; Multicellular organism; Cellular compartment; Endoplasmic reticulum; Peroxisome; Vacuole; Longevity; Mitophagy; Model organism; Cell; Genetics; Biochemistry; Gene; Autophagy; Cytoplasm; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008644321,0.0006974343,0.001033409,0.00008799146,0.001045904,0.0002272572,0.003687406,0.000594617,0.00001058469],"category_scores_gemma":[0.0001896468,0.0003071186,0.0004436228,0.000234163,0.00255531,0.000006178918,0.001846879,0.00111333,0.00001871994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007992378,"about_ca_system_score_gemma":0.0002335792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002514823,"about_ca_topic_score_gemma":0.0001097195,"domain_scores_codex":[0.9958271,0.001462437,0.0008812805,0.0007611125,0.0003608057,0.0007072425],"domain_scores_gemma":[0.9957284,0.0003196102,0.000510454,0.003258462,0.00007610138,0.0001070256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002151077,0.000369593,0.005642495,0.005040845,0.005239659,0.00002603626,0.007832477,0.0003350359,0.002975242,0.001576593,0.04166867,0.9290782],"study_design_scores_gemma":[0.0009954314,0.00005733202,0.0002456071,0.0006294573,0.0007550443,0.0001061861,0.0003840716,0.0001782673,0.000700098,0.0001393825,0.9952955,0.000513646],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005769223,0.9871048,0.001214239,0.002428161,0.0009173995,0.002003669,0.0002724387,0.00002587938,0.0002642177],"genre_scores_gemma":[0.01549362,0.9802236,0.00184044,0.0002326683,0.001167777,0.0002809786,0.0001537079,0.0001203841,0.0004868073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9536268,"threshold_uncertainty_score":0.9999381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697248868904806,"score_gpt":0.2521859949639861,"score_spread":0.235213506274938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}