{"id":"W2526145362","doi":"10.3389/fgene.2016.00177","title":"Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging","year":2016,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Biology; Saccharomyces cerevisiae; Organelle; Cell biology; Yeast; Mitochondrion; Cytosol; Multicellular organism; Cellular compartment; Endoplasmic reticulum; Peroxisome; Vacuole; Longevity; Mitophagy; Model organism; Cell; Genetics; Biochemistry; Gene; Autophagy; Cytoplasm; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533643,0.000361483,0.0003473738,0.0004485237,0.0002106162,0.0005216959,0.0002833998,0.0003422365,0.0002379615],"category_scores_gemma":[0.0001422207,0.0001403852,0.0002353716,0.0004708917,0.0004026153,0.0006428104,0.000285617,0.0003992158,0.0001281607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000576792,"about_ca_system_score_gemma":0.0003952354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008329584,"about_ca_topic_score_gemma":0.0008846536,"domain_scores_codex":[0.9999065,0.00001670852,0.00001334202,0.00002671083,0.00002166861,0.00001496123],"domain_scores_gemma":[0.9999055,0.00001804731,0.00004403766,0.000004176846,0.0000168698,0.00001142965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003818505,0.00003285502,0.002249327,0.004356979,0.00008871414,0.001967135,0.0007789612,0.002360688,0.7986974,0.01652901,0.001492707,0.1710643],"study_design_scores_gemma":[0.00005590203,0.0007450797,0.04164385,0.0009569403,0.000583947,0.004978243,0.001064292,0.002558757,0.5743949,0.01513162,0.3577431,0.0001434289],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1695892,0.8088963,0.01513815,0.0009568289,0.0003974497,0.0000351241,0.000480537,0.0002781698,0.004228345],"genre_scores_gemma":[0.4287801,0.5597579,0.007287917,0.0004126181,0.0002399698,0.00004272965,0.0005825228,0.00003106019,0.002865106],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008329584,"threshold_uncertainty_score":0.004184961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697248868904806,"score_gpt":0.2521859949639861,"score_spread":0.235213506274938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}