{"id":"W2526339802","doi":"10.1182/blood.v114.22.3259.3259","title":"FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Protein phosphatase 2; Dasatinib; Progenitor cell; Cancer research; Haematopoiesis; Stem cell; Tyrosine kinase; CD38; Myeloid leukemia; Biology; Chemistry; CD34; Cell biology; Phosphorylation; Phosphatase; Signal transduction; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006464643,0.0002189259,0.0001476904,0.00009681101,0.00009042971,0.0001626748,0.00009559004,0.0001645495,0.002765657],"category_scores_gemma":[0.00004839601,0.00005272247,0.0001204728,0.00006670259,0.00009995032,0.00009410712,0.00007333151,0.0002974178,0.0005419654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267831,"about_ca_system_score_gemma":0.0001495579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003732563,"about_ca_topic_score_gemma":0.0005440574,"domain_scores_codex":[0.9999671,0.000003836669,0.000002593195,0.000005540173,0.000008240417,0.00001262678],"domain_scores_gemma":[0.9999785,0.000003549355,0.000004739742,0.000001969546,0.000002487027,0.000008618836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003077534,0.00003328304,0.00007755805,0.00002463801,0.000002484268,0.0000328049,0.000002939366,0.00003761355,0.9964885,0.00005039829,0.00008123092,0.002860897],"study_design_scores_gemma":[0.0000408447,0.001129429,0.002511044,0.000003201445,0.00001153754,0.0002453044,0.000004699979,0.0002955701,0.9922724,0.00002496429,0.003458476,0.000002544018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897475,0.003611295,0.001165035,0.0001200925,0.00006744658,0.00005262758,0.0004454766,0.00008958206,0.004700894],"genre_scores_gemma":[0.9943726,0.001023685,0.0007112827,0.00003338219,0.00002868565,0.00001962947,0.0004352661,0.000009889209,0.003365489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002765657,"threshold_uncertainty_score":0.009252012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323204714167959,"score_gpt":0.2543781439404136,"score_spread":0.2411460967987341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}