{"id":"W2526348597","doi":"10.1212/wnl.86.16_supplement.pl01.002","title":"Discovery and Early Clinical Development of ISIS-HTTRx, the First HTT-Lowering Drug to Be Tested in Patients with Huntington’s Disease (PL01.002)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Huntington's disease; Medicine; Disease; Psychiatry; Gerontology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541689,0.0004437998,0.0003305294,0.0002709042,0.0001056269,0.0003864025,0.0002891934,0.0003984493,0.001712497],"category_scores_gemma":[0.0002261289,0.0001258727,0.0003100052,0.0001244441,0.0003128803,0.0002559996,0.0001879794,0.000874631,0.0004757668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003864725,"about_ca_system_score_gemma":0.0006316388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003662676,"about_ca_topic_score_gemma":0.001074356,"domain_scores_codex":[0.9998988,0.00001940735,0.000009035368,0.00002229123,0.00003208321,0.0000184186],"domain_scores_gemma":[0.9998918,0.00001225488,0.00002343249,0.000006299321,0.00002980501,0.00003640131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001740878,0.001215634,0.001804368,0.0005565375,0.00008031246,0.0007566494,0.0001883252,0.0007112159,0.8597016,0.001626493,0.001784761,0.1298331],"study_design_scores_gemma":[0.005764729,0.08592156,0.01564265,0.0002932184,0.0004857892,0.004409885,0.0001589736,0.003609146,0.7999567,0.0008901189,0.08280919,0.00005812963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9368358,0.02208483,0.02231428,0.001643801,0.0002777563,0.001416248,0.001294701,0.0003674676,0.01376517],"genre_scores_gemma":[0.9631967,0.01182841,0.01675943,0.0007684477,0.0001030225,0.0004030479,0.001281506,0.00003036601,0.005629168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712497,"threshold_uncertainty_score":0.0057289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200668562640916,"score_gpt":0.2573622445990446,"score_spread":0.2353555589726355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}