{"id":"W2526371770","doi":"10.1016/j.cjca.2016.07.246","title":"NOVEL WIDESPREAD MUTATION IN HIF1α IN SPRAGUE DAWLEY RATS IS ASSOCIATED WITH HYPER-RESPONSIVENESS TO SU5416 AND SEVERE PULMONARY ARTERIAL HYPERTENSION ONLY IN CONJUNCTION WITH OTHER SUB-STRAIN-SPECIFIC GENETIC MODIFIERS","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Hypoxia (environmental); Strain (injury); Pulmonary hypertension; Phenotype; Antagonist; Internal medicine; Pharmacology; Cardiology; Endocrinology; Receptor; Gene; Genetics; Oxygen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585107,0.001172003,0.000492513,0.00120231,0.0003215763,0.0002052504,0.0004236292,0.0004405561,0.00385436],"category_scores_gemma":[0.0002705596,0.0004497418,0.0005278868,0.0004075904,0.0009018818,0.0001549284,0.0006041408,0.000941502,0.0003694176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136994,"about_ca_system_score_gemma":0.000366366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001473376,"about_ca_topic_score_gemma":0.003105614,"domain_scores_codex":[0.9997163,0.00003655085,0.00003496709,0.00009356714,0.00006188299,0.00005677294],"domain_scores_gemma":[0.9991753,0.00008904289,0.0003707551,0.00006650408,0.00002941292,0.0002689894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006723066,0.0001133214,0.002531708,0.00002734766,0.00004191702,0.001772235,0.00003418806,0.00004345959,0.9937049,0.0001259125,0.00007200024,0.0008608175],"study_design_scores_gemma":[0.0003233051,0.003573378,0.324153,0.00003877851,0.0004427393,0.0333292,0.0005509276,0.001549811,0.6325637,0.0005841047,0.002747105,0.0001439529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984037,0.0001217464,0.0008083056,0.00005874273,0.00002547611,0.00001069815,0.0002577559,0.00005544391,0.0002581694],"genre_scores_gemma":[0.9972323,0.0001888687,0.0006407866,0.0000486752,0.00001697736,0.00002215747,0.0004148017,0.00004883011,0.001386773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00385436,"threshold_uncertainty_score":0.01289415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254117462733371,"score_gpt":0.2008523930056118,"score_spread":0.1883112183782781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}