{"id":"W2526459078","doi":"10.1139/bcb-2016-0137","title":"Precision genome editing in the CRISPR era","year":2016,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Genome editing; CRISPR; Cas9; Biology; Homology directed repair; Computational biology; Gene; Enhancer; Genome; Genome engineering; Genetics; DNA repair; Nucleotide excision repair; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006247528,0.0005686008,0.0008699562,0.001221312,0.0002121366,0.001040096,0.0007074121,0.001020439,0.002391821],"category_scores_gemma":[0.0004738896,0.0002328224,0.000472107,0.00107526,0.0005780256,0.001176301,0.0006599847,0.001991205,0.00136741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007138664,"about_ca_system_score_gemma":0.0007873665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007231795,"about_ca_topic_score_gemma":0.0008007509,"domain_scores_codex":[0.999755,0.00004134369,0.00002560159,0.00004423339,0.0001064534,0.00002743917],"domain_scores_gemma":[0.9997824,0.0001067037,0.0000271055,0.00001397362,0.00004602032,0.00002385716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004949141,0.00004277006,0.0001588775,0.0107207,0.0000837886,0.0003596676,0.0001085372,0.0007348816,0.01387782,0.01997122,0.02525974,0.9286326],"study_design_scores_gemma":[0.000005786499,0.00004205359,0.0003119624,0.0008593579,0.0000388391,0.001359235,0.00002458238,0.0001158828,0.003411359,0.003305607,0.9905078,0.00001750879],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004237416,0.9916449,0.00221806,0.0006232816,0.0003556419,0.000008888346,0.00003279535,0.00006318396,0.004629456],"genre_scores_gemma":[0.003077968,0.9923151,0.00160138,0.0004716449,0.0002450309,0.00001241322,0.0000590432,0.000009928729,0.002207488],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002391821,"threshold_uncertainty_score":0.008001447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123221310437633,"score_gpt":0.3220006004968184,"score_spread":0.3107683873924421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}