{"id":"W2526459078","doi":"10.1139/bcb-2016-0137","title":"Precision genome editing in the CRISPR era","year":2016,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Genome editing; CRISPR; Cas9; Biology; Homology directed repair; Computational biology; Gene; Enhancer; Genome; Genome engineering; Genetics; DNA repair; Nucleotide excision repair; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000330793,0.0003606544,0.000497991,0.00004287623,0.0000617147,0.00002213641,0.0004117509,0.0007154583,0.00002505106],"category_scores_gemma":[0.00006958564,0.000220597,0.0001850905,0.00008337109,0.0001025459,0.000001251163,0.0001964643,0.0002683263,0.00001242677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001432501,"about_ca_system_score_gemma":0.00007700602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002511578,"about_ca_topic_score_gemma":0.00000118863,"domain_scores_codex":[0.9984986,0.0001076423,0.000383044,0.0006019943,0.00005990603,0.0003487761],"domain_scores_gemma":[0.9992312,0.00007152583,0.0001310398,0.0004826352,0.0000210066,0.00006262474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000112316,0.00004801782,0.00001374591,0.003476732,0.00004966196,0.00001015424,0.00002955173,8.098535e-7,0.1387234,0.00001424526,0.0008011776,0.8568213],"study_design_scores_gemma":[0.0001645473,0.00006934404,0.000004018827,0.0005079244,0.00004785486,0.00005941121,0.00002741618,5.723568e-7,0.01354586,0.00001508208,0.9852735,0.0002844182],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009216395,0.9957702,0.0003384149,0.00002591541,0.0001754447,0.0002464708,0.0000829175,0.000007975798,0.002431055],"genre_scores_gemma":[0.005327366,0.9923114,0.0000919212,0.00004989497,0.001142688,0.0000776267,0.0004488999,0.00002845021,0.0005217129],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9844724,"threshold_uncertainty_score":0.8995686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123221310437633,"score_gpt":0.3220006004968184,"score_spread":0.3107683873924421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}