{"id":"W2526646582","doi":"10.1093/biolreprod/85.s1.622","title":"FoxA2 Mediates Monosaccharide-Induced Repression of SHBG Gene Expression by Regulating Lipid Homeostasis in HepG2 Cells.","year":2011,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"FOXA2; Biology; Sex hormone-binding globulin; Endocrinology; Hepatocyte nuclear factor 4; Internal medicine; Glucose homeostasis; Reporter gene; Transcription factor; Hepatocyte nuclear factors; Gene expression; Nuclear receptor; Hormone; Gene; Biochemistry; Androgen; Medicine; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364728,0.0001592984,0.0002511027,0.0001326107,0.00003781589,0.000002171424,0.0001449693,0.0003189153,0.00003200598],"category_scores_gemma":[0.0001616009,0.0001508757,0.00008333268,0.0001487875,0.0001234876,0.00001711215,0.00005842916,0.00008797202,0.000001536099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001652218,"about_ca_system_score_gemma":0.0000264944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002012955,"about_ca_topic_score_gemma":0.0000105396,"domain_scores_codex":[0.9983416,0.0001653905,0.0005348116,0.0006777275,0.0001003991,0.000180073],"domain_scores_gemma":[0.9987783,0.00001033885,0.0004119072,0.0006293936,0.0001299345,0.00004013288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002580116,0.0001176546,0.01330299,0.00003103584,0.00001743145,1.461711e-7,0.0002535916,0.00002048004,0.9749365,0.000008424405,0.0001992528,0.01085441],"study_design_scores_gemma":[0.0004140735,0.0003296639,0.01822286,0.00003485693,0.000009946525,0.00000367841,0.00008436743,0.00001747265,0.9801402,0.0001065943,0.0004995934,0.0001367107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996423,0.002016191,0.0006661905,0.00004753461,0.0004983876,0.0002427066,0.00002190466,0.00001826286,0.00006578671],"genre_scores_gemma":[0.9952442,0.0005551737,0.003745752,0.000004685244,0.0001370376,0.00001812694,0.0002329175,0.00001831762,0.00004381254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0107177,"threshold_uncertainty_score":0.6152531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02730874210552557,"score_gpt":0.2488720736153149,"score_spread":0.2215633315097894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}